2019
Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2017
Sunday in the Park with Infectious Disease: Workforce Mismatch in a Colorful Universe of Possibilities
Moore T, Dembry LM, Saag MS. Sunday in the Park with Infectious Disease: Workforce Mismatch in a Colorful Universe of Possibilities. The Journal Of Infectious Diseases 2017, 216: s581-s587. PMID: 28938044, PMCID: PMC5853217, DOI: 10.1093/infdis/jix323.Peer-Reviewed Original Research
2016
Epidemiology of Clostridium difficile infection in hospitalized oncology patients
Chang GY, Dembry LM, Banach DB. Epidemiology of Clostridium difficile infection in hospitalized oncology patients. American Journal Of Infection Control 2016, 44: 1421-1423. PMID: 27287733, DOI: 10.1016/j.ajic.2016.04.210.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionBlood transfusionDifficile infectionHistory of CDIΒ-lactam/β-lactamase inhibitorsBroad-spectrum antibiotic useHospitalized oncology patientsRecent blood transfusionCDI historyCDI riskOlder patientsOncology inpatientsΒ-lactamase inhibitorsOncology patientsPrior receiptRisk factorsAntibiotic useMultivariate analysisTransfusionPatientsInfectionEpidemiologyInpatientsMetronidazoleCephalosporinsThe clinical and molecular epidemiology of pre‐transplant vancomycin‐resistant enterococci colonization among liver transplant recipients
Banach DB, Peaper DR, Fortune BE, Emre S, Dembry LM. The clinical and molecular epidemiology of pre‐transplant vancomycin‐resistant enterococci colonization among liver transplant recipients. Clinical Transplantation 2016, 30: 306-311. PMID: 26780305, DOI: 10.1111/ctr.12690.Peer-Reviewed Original ResearchConceptsLiver transplant recipientsLiver transplantationVRE colonizationTransplant recipientsVancomycin-resistant enterococci (VRE) infectionPolymerase chain reaction testingVancomycin-resistant enterococci colonizationPre-transplant colonizationSubsequent liver transplantationMore hospital daysObservational cohort studyCentral venous catheterizationInfection prevention measuresWarrants further studyRifaximin useAntimicrobial prophylaxisCohort studyHospital daysSignificant morbidityVenous catheterizationProspective studyActive surveillanceRisk factorsSurveillance culturesVRE isolates
2015
Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program
Nelson MU, Bizzarro MJ, Baltimore RS, Dembry LM, Gallagher PG. Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program. Journal Of Clinical Microbiology 2015, 53: 2492-2501. PMID: 26019206, PMCID: PMC4508396, DOI: 10.1128/jcm.00470-15.Peer-Reviewed Original ResearchMeSH KeywordsDNA, BacterialEpidemiological MonitoringFemaleGenetic VariationGenotypeGenotyping TechniquesHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMethicillin-Resistant Staphylococcus aureusMolecular EpidemiologyMolecular TypingRetrospective StudiesStaphylococcal InfectionsVirulence FactorsConceptsNeonatal intensive care unitMethicillin-resistant Staphylococcus aureusIntensive care unitMRSA colonizationMolecular epidemiologyCare unitStaphylococcal cassette chromosome mec type IIAccessory gene regulator (agr) groupsMRSA colonization rateToxic shock syndrome toxinAgr group 1Exfoliative toxin AStaphylococcus aureusPotential virulence factor genesVirulence factor genesMRSA infectionSignificant morbidityClinical differencesPatient daysPulsed-field gel electrophoresisToxin AUSA300 strainGroup 1Continued vigilanceInfectionNeonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci
Bizzarro MJ, Shabanova V, Baltimore RS, Dembry LM, Ehrenkranz RA, Gallagher PG. Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci. The Journal Of Pediatrics 2015, 166: 1193-1199. PMID: 25919728, PMCID: PMC4413005, DOI: 10.1016/j.jpeds.2015.02.009.Peer-Reviewed Original ResearchConceptsEarly-onset sepsisLate-onset sepsisNeonatal intensive care unitCoagulase-negative staphylococciIntensive care unitCare unitLevel IV neonatal intensive care unitEpisodes of sepsisLow birth weightInfection prevention initiativesInfection prevention effortsPercent of casesGroup B streptococciHospital courseSepsis episodesMost infantsBirth weightCommon organismB streptococciSepsisOutcome dataAdditional surveillancePrevention effortsStudy periodInfants
2013
Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial
Harris AD, Pineles L, Belton B, Johnson JK, Shardell M, Loeb M, Newhouse R, Dembry L, Braun B, Perencevich EN, Hall KK, Morgan DJ, Shahryar S, Price C, Gadbaw J, Drees M, Kett D, Muñoz-Price L, Jacob J, Herwaldt L, Sulis C, Yokoe D, Maragakis L, Lissauer M, Zervos M, Warren D, Carver R, Anderson D, Calfee D, Bowling J, Safdar N. Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial. JAMA 2013, 310: 1571-1580. PMID: 24097234, PMCID: PMC4026208, DOI: 10.1001/jama.2013.277815.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross InfectionEnterococcusFemaleGloves, ProtectiveGram-Positive Bacterial InfectionsGuideline AdherenceHand DisinfectionHumansInfection ControlIntensive Care UnitsMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedPersonnel, HospitalStaphylococcal InfectionsSurgical AttireVancomycin ResistanceConceptsIntensive care unitMethicillin-resistant Staphylococcus aureusVancomycin-resistant EnterococcusIntervention ICUsSurgical intensive care unitPrimary outcomeHand hygiene complianceSecondary outcomesAdverse eventsPatient contactUniversal gloveVRE acquisitionUsual careMRSA acquisitionGown useHygiene complianceAcquisition of MRSAAntibiotic-resistant bacteriaControl intensive care unitHealth care-associated infectionsStudy periodKey secondary outcomesBaseline periodCare-associated infectionsHealth care workers
2008
Matched Case-Control Analysis of Polymicrobial Bloodstream Infection In A Neonatal Intensive Care Unit
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Matched Case-Control Analysis of Polymicrobial Bloodstream Infection In A Neonatal Intensive Care Unit. Infection Control And Hospital Epidemiology 2008, 29: 914-920. PMID: 18808341, DOI: 10.1086/591323.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaCase-Control StudiesFemaleFungemiaFungiGram-Negative BacteriaGram-Negative Bacterial InfectionsGram-Positive BacteriaGram-Positive Bacterial InfectionsHumansIncidenceInfant, Low Birth WeightInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInfant, Very Low Birth WeightIntensive Care Units, NeonatalMaleRisk FactorsConceptsPolymicrobial bloodstream infectionsMonomicrobial bloodstream infectionSevere underlying conditionsBloodstream infectionsOnset of infectionUnderlying conditionRisk factorsMultivariate analysisIndwelling central venous catheterIntensive care unit patientsNeonatal intensive care unitMatched Case-Control AnalysisIndependent risk factorNewborn intensive care unit (NICU) patientsCare unit patientsCentral venous cathetersIntensive care unitNeonatal bloodstream infectionsMost risk factorsCase-control studyCase-control analysisCoagulase-negative staphylococciHospital NICUUnit patientsVenous cathetersChanging Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis. Pediatrics 2008, 121: 689-696. PMID: 18381532, DOI: 10.1542/peds.2007-2171.Peer-Reviewed Original ResearchMeSH KeywordsAmpicillinAmpicillin ResistanceAntibiotic ProphylaxisBacteremiaEscherichia coliEscherichia coli InfectionsFemaleFollow-Up StudiesHumansIncidenceInfant, NewbornInfectious Disease Transmission, VerticalMaleMultivariate AnalysisOdds RatioPregnancyPregnancy Complications, InfectiousPrenatal CareProbabilityRetrospective StudiesRisk AssessmentSeverity of Illness IndexStatistics, NonparametricSurvival RateConceptsE. coli early-onset sepsisEarly-onset sepsisLate-onset sepsisYale-New Haven HospitalIntrapartum antibiotic prophylaxisAntibiotic prophylaxisColi sepsisLow birth weight infantsAmpicillin resistanceAntibiotic prophylaxis practiceIntrapartum antibiotic exposureBirth weight infantsE. coli sepsisIndependent risk factorEscherichia coli sepsisAmpicillin exposureAmpicillin-resistant E. coliProphylaxis practicesSepsis rateWeight infantsNeonatal sepsisPreterm infantsTerm infantsRetrospective reviewRisk factors
2007
Trends in Prescribing β-Lactam Antibiotics for Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus Infections
Gupta K, MacIntyre A, Vanasse G, Dembry LM. Trends in Prescribing β-Lactam Antibiotics for Treatment of Community-Associated Methicillin-Resistant Staphylococcus aureus Infections. Journal Of Clinical Microbiology 2007, 45: 3930-3934. PMID: 17942648, PMCID: PMC2168566, DOI: 10.1128/jcm.01510-07.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-LactamsChildChild, PreschoolCommunity-Acquired InfectionsDrug PrescriptionsFemaleHealth Services ResearchHumansInfantInfant, NewbornMaleMethicillin ResistanceMiddle AgedPrevalenceStaphylococcal InfectionsStaphylococcus aureusUnited StatesConceptsCA-MRSA soft tissue infectionsSoft tissue infectionsInitial empirical therapyCA-MRSA isolatesEmpirical therapyAntimicrobial therapyCommunity-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolatesStaphylococcal chromosomal cassette mec type IVS. aureus soft tissue infectionsResistant Staphylococcus aureus infectionsMethicillin-Resistant Staphylococcus aureus IsolatesInactive antimicrobial therapyRate of prescribingCA-MRSA infectionsInitial antimicrobial therapyMajority of patientsMedical record reviewSubset of patientsCommunity-Associated MethicillinStaphylococcus aureus infectionPanton-Valentine leukocidinStaphylococcus aureus isolatesBeta-lactam antibioticsDiscordant therapyRate of useCase-control analysis of endemic Serratia marcescens bacteremia in a neonatal intensive care unit
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Case-control analysis of endemic Serratia marcescens bacteremia in a neonatal intensive care unit. Archives Of Disease In Childhood - Fetal And Neonatal Edition 2007, 92: f120. PMID: 17088342, PMCID: PMC2675455, DOI: 10.1136/adc.2006.102855.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaBirth WeightCase-Control StudiesConnecticutCross InfectionDrug Resistance, BacterialEndemic DiseasesEscherichia coliEscherichia coli InfectionsFemaleHumansInfant, NewbornIntensive Care Units, NeonatalMaleMicrobial Sensitivity TestsPrognosisRisk FactorsSerratia InfectionsSerratia marcescensConceptsNeonatal intensive care unitIntensive care unitCare unitUninfected controlsHospital Neonatal Intensive Care UnitSerratia marcescens bacteremiaMedian gestational ageCentral vascular catheterEscherichia coli bacteremiaRecords of infantsCase-control studyHigher overall mortalityE coliOnset of infectionCase-control analysisTime of infectionHigh rateAssociated meningitisHospital courseColi bacteremiaOverall mortalityGestational agePremature infantsVascular cathetersBirth weight
2004
Conjunctival Colonization of Infants Hospitalized in a Neonatal Intensive Care Unit: A Longitudinal Analysis
Raskind CH, Sabo BE, Callan DA, Farrel PA, Dembry LM, Gallagher PG. Conjunctival Colonization of Infants Hospitalized in a Neonatal Intensive Care Unit: A Longitudinal Analysis. Infection Control And Hospital Epidemiology 2004, 25: 216-220. PMID: 15061413, DOI: 10.1086/502381.Peer-Reviewed Original Research
2000
Molecular Typing Demonstrating Transmission of Gram-Negative Rods in a Neonatal Intensive Care Unit in the Absence of a Recognized Epidemic
Almuneef M, Baltimore R, Farrel P, Reagan-Cirincione P, Dembry L. Molecular Typing Demonstrating Transmission of Gram-Negative Rods in a Neonatal Intensive Care Unit in the Absence of a Recognized Epidemic. Clinical Infectious Diseases 2000, 32: 220-227. PMID: 11170911, DOI: 10.1086/318477.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial Typing TechniquesCross InfectionDNA, BacterialDrug Resistance, MicrobialElectrophoresisFecesFemaleGenotypeGentamicinsGram-Negative Aerobic Rods and CocciGram-Negative Bacterial InfectionsHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMicrobial Sensitivity TestsConceptsNeonatal intensive care unitIntensive care unitShared strainsCare unitMolecular typing techniquesRectal swab culturesColonization of infantsGentamicin-resistant strainsWeeks of ageTyping techniquesAntibiotic treatmentAntibiotic useSwab culturesGram-negative rodsGentamicin susceptibilityInfantsTotal daysOutbreak investigationIdentical strainsNegative rodsUnique strainsHigh rateContour-clamped homogeneous electric field electrophoresisAdmissionGentamicin
1999
A Decade of Prevalence Surveys in a Tertiary-Care Center: Trends in Nosocomial Infection Rates, Device Utilization, and Patient Acuity
Weinstein J, Mazon D, Pantelick E, Reagan-Cirincione P, Dembry L, Hierholzer W. A Decade of Prevalence Surveys in a Tertiary-Care Center: Trends in Nosocomial Infection Rates, Device Utilization, and Patient Acuity. Infection Control And Hospital Epidemiology 1999, 20: 543-548. PMID: 10466554, DOI: 10.1086/501675.Peer-Reviewed Original ResearchConceptsNosocomial infection ratesAcute care patientsNosocomial bloodstream infectionsPrevalence surveyNosocomial infectionsInfection rateBloodstream infectionsPotential quality improvement initiativesAbnormal laboratory indicatorsAnnual prevalence surveysInvasive device utilizationTertiary care centerAbnormal laboratory valuesSeverity of illnessAcute care bedsInfection control practitionersSurveillance System dataRate of infectionQuality improvement initiativesObstetric-gynecologic servicesCase mix indexChart reviewCare patientsFoley catheterLaboratory indicators
1998
Nosocomial Candida glabrata Colonization: an Epidemiologic Study
Vazquez J, Dembry L, Sanchez V, Vazquez M, Sobel J, Dmuchowski C, Zervos M. Nosocomial Candida glabrata Colonization: an Epidemiologic Study. Journal Of Clinical Microbiology 1998, 36: 421-426. PMID: 9466752, PMCID: PMC104553, DOI: 10.1128/jcm.36.2.421-426.1998.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBone Marrow TransplantationCandidaCandidiasisChildChild, PreschoolCross InfectionDNA, FungalEnvironmental MicrobiologyFemaleHandHealth PersonnelHospitalizationHospitals, UniversityHumansIntensive Care UnitsMaleMiddle AgedMolecular EpidemiologyPolymorphism, Restriction Fragment LengthProspective StudiesRisk FactorsConceptsNosocomial acquisitionC. glabrataMedical intensive care unitBone marrow transplant unitPrior antimicrobial useDuration of hospitalizationIntensive care unitMarrow transplant unitSignificant risk factorsImportant nosocomial pathogenStrain typesSame strain typeCare unitTransplant unitUniversity HospitalRisk factorsEpidemiologic studiesPatientsC. glabrata strainsEnvironmental surfacesHospital personnelNosocomial pathogenAntimicrobial useIdentical strainsHospital environment
1997
RENAL AND PERIRENAL ABSCESSES
Dembry LM, Andriole VT. RENAL AND PERIRENAL ABSCESSES. Infectious Disease Clinics Of North America 1997, 11: 663-680. PMID: 9378929, DOI: 10.1016/s0891-5520(05)70379-2.Peer-Reviewed Original ResearchConceptsRenal cortical abscessCortical abscessesIntrarenal abscessAntibiotic therapyAcute multifocal bacterial nephritisAcute focal bacterial nephritisFocal bacterial nephritisRenal corticomedullaryPerirenal abscessRenal abscessSerious prognosisXanthogranulomatous pyelonephritisClinical presentationElusive diagnosisNegative uropathogensAntistaphylococcal therapyComplete nephrectomyAbscessRadiographic studiesRadiologic techniquesTherapyNephritisDiagnosisPyelonephritisNephrectomy
1996
Control of endemic glycopeptide-resistant enterococci.
Dembry LM, Uzokwe K, Zervos MJ. Control of endemic glycopeptide-resistant enterococci. Infection Control And Hospital Epidemiology 1996, 17: 286-92. PMID: 8727617, DOI: 10.1086/647297.Peer-Reviewed Original ResearchConceptsVancomycin-resistant EnterococcusRenal unitsEradication of carriageVRE stool colonizationCommunity teaching hospitalPatient carriageBarrier precautionsOral doxycyclineFurther patientsStool colonizationGlycopeptide-resistant enterococciCulture surveyTeaching hospitalPatientsStudy periodEnterococcus faeciumEnterococcus gallinarumCarriageRifampinDoxycyclineEnterococcusControl measuresDaysUseful measureHospital
1995
Invasive Candida guilliermondii infection: in vitro susceptibility studies and molecular analysis.
Vazquez J, Lundstrom T, Dembry L, Chandrasekar P, Boikov D, Parri M, Zervos M. Invasive Candida guilliermondii infection: in vitro susceptibility studies and molecular analysis. Bone Marrow Transplantation 1995, 16: 849-53. PMID: 8750282.Peer-Reviewed Original ResearchConceptsHigh-dose amphotericin BMinimum inhibitory concentration (MIC) rangeSustained neutropeniaPurulent pericarditisAplastic anemiaC. guilliermondiiInhibitory concentration rangePoor responseClinical isolatesAmphotericin BProlonged durationHigh MICsInitial misidentificationTherapyEnvironmental isolatesIsolatesControl strainMolecular analysisNeutropeniaPericarditisFungemiaAnemiaBMTFlucytosineAmB
1993
Nosocomial Acquisition of Candida albicans: An Epidemiologic Study
Vazquez J, Sanchez V, Dmuchowski C, Dembry L, Sobel J, Zervos M. Nosocomial Acquisition of Candida albicans: An Epidemiologic Study. The Journal Of Infectious Diseases 1993, 168: 195-201. PMID: 8515108, DOI: 10.1093/infdis/168.1.195.Peer-Reviewed Original ResearchConceptsNosocomial acquisitionMedical intensive care unitBone marrow transplant unitIntensive care unitMarrow transplant unitIndirect patient contactC. albicansPrior antibioticsCare unitProspective studyTransplant unitUniversity HospitalRisk factorsEpidemiologic studiesPatient contactPatientsEnvironmental surfacesHospital personnelCandida albicansIdentical strainsStrain typesAdmissionLength of timeRestriction enzyme analysisAlbicansNosocomial acquisition of Candida parapsilosis: An epidemiologic study
Sanchez V, Vazquez J, Barth-Jones D, Dembry L, Sobel J, Zervos M. Nosocomial acquisition of Candida parapsilosis: An epidemiologic study. The American Journal Of Medicine 1993, 94: 577-582. PMID: 8389525, DOI: 10.1016/0002-9343(93)90207-6.Peer-Reviewed Original ResearchConceptsIntensive care unitC. parapsilosisMedicine intensive care unitBone marrow transplant unitNegative initial culturesTertiary care hospitalMarrow transplant unitLittle epidemiologic informationHands of personnelImportant nosocomial pathogenStrain typesRestriction enzyme analysisCandida parapsilosisEnvironmental surfacesImmunosuppressive therapyNosocomial acquisitionAntibiotic therapyCare hospitalCare unitTransplant unitControl subjectsHand culturesNosocomial infectionsPatient strainsEpidemiologic information