2014
Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm
Golden D, Cantley LG. Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm. Oncogene 2014, 34: 4702-4712. PMID: 25486430, PMCID: PMC4459945, DOI: 10.1038/onc.2014.395.Peer-Reviewed Original ResearchConceptsCK2β regulatory subunitSerine 124Epithelial-mesenchymal transitionRegulatory subunitNuclear localizationCytoplasmic localizationCasein kinase 2 phosphorylation sitesDevelopmental epithelial-mesenchymal transitionMesenchymal transformationCell migrationEpithelial cellsDe novo accumulationCK2 associatesTranscriptional regulatorsMalignant breast cancer cellsPhosphorylation sitesCK2β expressionKinase subunitMesenchymal genesBreast epithelial cellsProper targetingAmino terminusNormal breast epithelial cellsNormal epithelial cellsLeucine promotesHepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling*
Koraishy FM, Silva C, Mason S, Wu D, Cantley LG. Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling*. Journal Of Biological Chemistry 2014, 289: 14341-14350. PMID: 24692544, PMCID: PMC4022900, DOI: 10.1074/jbc.m114.563213.Peer-Reviewed Original ResearchConceptsΒ-catenin stabilizationRenal ischemic injuryLRP5/6 phosphorylationEpithelial cell responsesRenal proximal tubulesEpithelial cell apoptosisHepatocyte growth factorCanonical WntActive GSK3Ischemic injuryRenal epithelial cellsProximal tubulesCell responsesCanonical Wnt signalingHGF treatmentGrowth factorCell apoptosisEpithelial cellsHGFMet receptorImportant transactivatorWnt signalingInjuryLRP5/6MetS
2013
Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft Function
Schmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR, Cantley LG. Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft Function. Journal Of The American Society Of Nephrology 2013, 24: 309-319. PMID: 23291472, PMCID: PMC3559482, DOI: 10.1681/asn.2012060579.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAnimalsApoptosisBiomarkersCells, CulturedChitinase-3-Like Protein 1Delayed Graft FunctionDisease Models, AnimalEpithelial CellsGlycoproteinsHumansKidneyKidney TransplantationLectinsMacrophagesMaleMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesPredictive Value of TestsProto-Oncogene Proteins c-aktReperfusion InjurySignal TransductionTransplantation, HomologousConceptsBRP-39/YKLGraft functionKidney injuryYKL-40Reparative responseDeceased donor kidney transplantationKidney ischemia/reperfusionHours of transplantImmediate graft functionDelayed graft functionTubular cell deathIschemia/reperfusionDegree of injuryAllograft functionCell apoptotic deathKidney hypoperfusionKidney transplantationSystemic hypotensionRenal failureIschemic injuryRenal ischemiaRenal responseUrinary levelsBRP-39Activation of Akt
2001
ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*
Yu C, Roshan B, Liu Z, Cantley L. ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*. Journal Of Biological Chemistry 2001, 276: 32552-32558. PMID: 11445578, DOI: 10.1074/jbc.m104493200.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBinding SitesButadienesCell LineCulture Media, Serum-FreeEnzyme ActivationEnzyme InhibitorsEpithelial CellsHepatocyte Growth FactorKineticsMitogen-Activated Protein KinasesNitrilesPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphopeptidesPhosphoproteinsPhosphothreoninePhosphotyrosineProtein SubunitsRecombinant Fusion ProteinsSrc Homology DomainsHGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner
Liu Z, Nickel C, Cantley L. HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. American Journal Of Physiology. Renal Physiology 2001, 281: f62-f70. PMID: 11399647, DOI: 10.1152/ajprenal.2001.281.1.f62.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseATP-depleted cellsHepatocyte growth factorCell adhesionAddition of HGFATP depletionExtracellular signal-regulated kinase (ERK) phosphorylationMAPK-dependent mannerSignal-regulated kinase phosphorylationLoss of adhesionDuct 3 cellsEffects of HGFProtein kinaseERK activationMAPK pathwayKinase phosphorylationRenal tubular epithelial cellsEpithelial cellsAdherent cellsGrowth factorCellsATPTubular epithelial cellsPathwayAdhesion
2000
Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells.
O'Rourke DA, Liu ZX, Sellin L, Spokes K, Zeller R, Cantley L. Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. Journal Of The American Society Of Nephrology 2000, 11: 2212-2221. PMID: 11095644, DOI: 10.1681/asn.v11122212.Peer-Reviewed Original ResearchConceptsFormin isoformsHepatocyte growth factorRenal epithelial cellsEpithelial tubule formationProtein kinase-dependent mannerUreteric bud outgrowthExtracellular signal-regulated kinaseQuiescent epithelial cellsEpithelial cellsFamily of proteinsProtein kinase inhibitor U0126Mitogen-activated protein kinase-dependent mannerKinase-dependent mannerMitogen-activated protein kinase inhibitor U0126Kinase inhibitor U0126Cell-matrix interactionsCell-cell interactionsGrowth factorSignal-regulated kinaseTubule formationSoluble cell lysateRapid relocalizationPhosphorylation substratesActin cytoskeletonCellular relocalization
1999
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells
O’Rourke D, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L. Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. American Journal Of Physiology 1999, 276: f581-f588. PMID: 10198418, DOI: 10.1152/ajprenal.1999.276.4.f581.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementCell SurvivalCollagenDogsDrosophila ProteinsEpithelial CellsGlial Cell Line-Derived Neurotrophic Factor ReceptorsHepatocyte Growth FactorKidneyKidney MedullaKidney Tubules, CollectingMicePhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesConceptsGlial-derived neurotropic factorCell survivalEpidermal growth factorC-RetHepatocyte growth factorProtein tyrosine kinase receptorsEpithelial cell morphogenesisEarly branching morphogenesisTyrosine-phosphorylated receptorsUreteric bud developmentProcess formationSpiny cystsCell morphogenesisTyrosine kinase receptorsEpithelial morphogenesisGrowth factorBranching morphogenesisExamination of mRNAEGF receptorMorphogenesisStable expressionKinase receptorsBud developmentSerum-free conditionsEarly regulation