2021
Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development
Barsky M, Merkison J, Hosseinzadeh P, Yang L, Bruno-Gaston J, Dunn J, Gibbons W, Blesson C. Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development. The Journal Of Steroid Biochemistry And Molecular Biology 2021, 207: 105830. PMID: 33515680, PMCID: PMC8056856, DOI: 10.1016/j.jsbmb.2021.105830.Peer-Reviewed Original ResearchConceptsGene expressionPolycystic ovary syndromeOvarian developmentDifferential gene expressionFetal gonadal developmentDownregulated genesTranscriptional pathwaysCandidate genesMitochondrial studiesMitochondrial oxygen consumptionProton leakOvary syndromeGonadal developmentMitochondrial functionFetal programmingMitochondrial ultrastructureStrong hereditary componentMitochondrial dysfunctionMitochondrial efficiencyMitochondriaAndrogen exposureGenesInheritance patternOocyte maturationAndrogen programming
2012
Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice
Rossi L, Lin K, Boles N, Yang L, King K, Jeong M, Mayle A, Goodell M. Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice. Cell Stem Cell 2012, 11: 302-317. PMID: 22958929, PMCID: PMC3461270, DOI: 10.1016/j.stem.2012.08.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHematopoietic stem cellsHSC functionSomatic stem cell typesCell cycle controlStem cellsPTEN/AKTKey regulatory pathwaysStem cell typesTGF-β signalingKnockout miceHSC biologyRegulatory pathwaysCycle controlGenetic analysisCell typesFunctional coreFunctional modulesCellsWntCohesive pictureGenesSignalingBiologyAktMice