Lingjuan Hong, PhD
Associate Research Scientist in GeneticsDownloadHi-Res Photo
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Lingjuan Hong's published research.
Publications Timeline
A big-picture view of Lingjuan Hong's research output by year.
Arya Mani, MD, FACC, FAHA
Sameet Mehta, PhD
Caroline Hendry, PhD
Curt Scharfe, MD, PhD, FACMG
David van Dijk, PhD, MSc, BSc
James Noonan, PhD
16Publications
819Citations
Publications
2023
A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension
Gunawardhana K, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni D, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan J, Mani A. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. Journal Of Clinical Investigation 2023, 133: e160036. PMID: 36602864, PMCID: PMC9927944, DOI: 10.1172/jci160036.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDevelopment of hypertensionParallel reporter assaysRenin inhibitor aliskirenNeural crest-derived cellsRenin-producing cellsSystems biology approachRNA-seq analysisCell-specific disruptionCrest-derived cellsSmooth muscle cellsMuscle cell proteinsSystemic hypertensionBlood pressureWT miceAntihypertensive drugsBiology approachSuper enhancersFine mappingWT littermatesThird intronMultiple GWASCollagen depositionMouse aortaReporter assaysFate mapping
2022
Prdm6 controls heart development by regulating neural crest cell differentiation and migration
Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight 2022, 7: e156046. PMID: 35108221, PMCID: PMC8876496, DOI: 10.1172/jci.insight.156046.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCardiac NCCNeural crest cell fateNeural crest cell differentiationSingle-cell RNA-seq analysisRNA-seq analysisDorsal neural tubeG1-S progressionFate-mapping approachCNCC migrationSpecification genesH4K20 monomethylationCell fateTranscriptomic analysisEpigenetic modifiersHeart developmentRegulated networkTranscript levelsKey regulatorMolecular mechanismsCell differentiationNeural tubePRDM6Ductus arteriosusPotential targetDifferentiation
2018
Cathepsin B inhibition ameliorates leukocyte‐endothelial adhesion in the BTBR mouse model of autism
Wang H, Yin Y, Gong D, Hong L, Wu G, Jiang Q, Wang C, Blinder P, Long S, Han F, Lu Y. Cathepsin B inhibition ameliorates leukocyte‐endothelial adhesion in the BTBR mouse model of autism. CNS Neuroscience & Therapeutics 2018, 25: 476-485. PMID: 30328295, PMCID: PMC6488924, DOI: 10.1111/cns.13074.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLeukocyte-endothelial adhesionTwo-photon laser scanning microscopyCerebral vesselsNeurovascular inflammationBTBR micePharmacological inhibitionMRNA expressionProtein levels of cathepsin BPharmacological inhibition of cathepsin BBTBR T+tf/J miceExpression of cell adhesion moleculesEndothelial ICAM-1Protein levelsLevels of cathepsin BBTBR mouse modelCXCL7 levelsCathepsin BCathepsin B levelsNeutrophil CD11bCell adhesion moleculesICAM-1Autistic miceAutism spectrum disorderClinical challengePathophysiological mechanismsEndothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation
Gong D, Zhang Y, Chen D, Hong L, Han F, Liu Q, Jiang J, Lu Y. Endothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation. Cellular Physiology And Biochemistry 2018, 45: 547-557. PMID: 29402834, DOI: 10.1159/000487032.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticAtherosclerosisCaspase 1CholesterolCholesterol, LDLDiet, High-FatDisease Models, AnimalHumansInflammationMiceMice, Inbred C57BLMice, TransgenicMyocytes, Smooth MuscleNLR Family, Pyrin Domain-Containing 3 ProteinPeroxynitrous AcidPlasmidsReceptors, G-Protein-CoupledSinus of ValsalvaConceptsAortic sinusProgression of atherosclerosisElevated proliferationAnimal modelsTie-2 promoterPathological processesProliferation of smooth muscle cellsUp-regulation of CD68Smooth muscle cellsEndothelial cell dysfunctionAtherosclerotic cardiovascular diseaseG protein-coupled receptor 124Pathological progressionAnimal models of atherosclerosisCaspase-1 levelsHigh-fat dietPathogenesis of atherosclerosisModel of atherosclerosisAdult miceLDL-CTie-2Immunohistochemistry methodTotal cholesterolCell dysfunctionMuscle cells
2017
BNGR-A25L and -A27 are two functional G protein–coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx mori
Shen Z, Chen Y, Hong L, Cui Z, Yang H, He X, Shi Y, Shi L, Han F, Zhou N. BNGR-A25L and -A27 are two functional G protein–coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm Bombyx mori. Journal Of Biological Chemistry 2017, 292: 16554-16570. PMID: 28842502, PMCID: PMC5633119, DOI: 10.1074/jbc.m117.803445.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAmino acidsDominant-negative proteinC-terminal tailSilkworm Bombyx moriAmino acid residuesInhibitor-sensitive mannerFunctional G protein-coupled receptorsG protein-coupled receptorsAcid residuesShort isoformBombyx moriInsect modelCapa receptorSplice variantsInsect biologySignaling pathwayReceptor internalizationCAPA peptidesCAPA-PVKERK1/2 phosphorylationEndocrinological rolesCognate receptorsInsect neuropeptidesNonfunctional receptorsFunctional assays
2015
Novel 1‑Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease
Sheng R, Tang L, Jiang L, Hong L, Shi Y, Zhou N, Hu Y. Novel 1‑Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease. ACS Chemical Neuroscience 2015, 7: 69-81. PMID: 26479744, DOI: 10.1021/acschemneuro.5b00224.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCompound 5cH3 receptor antagonismPotential multifunctional candidateNanomolar IC50 valuesMultifunctional agentsRadical cationMetal ion chelatorsBiological evaluationMultifunctional candidateChelating propertiesCompoundsH3 receptor antagonistsIon chelationIC50 valuesTherapy of Alzheimer's diseaseDerivativesPharmacokinetic propertiesRadical scavengingMoietyCationsMicromolar concentrationsAggregation inhibitionChelationPropertiesMetalVisualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury
Li X, Tao R, Hong L, Cheng J, Jiang Q, Lu Y, Liao M, Ye W, Lu N, Han F, Hu Y, Hu Y. Visualizing Peroxynitrite Fluxes in Endothelial Cells Reveals the Dynamic Progression of Brain Vascular Injury. Journal Of The American Chemical Society 2015, 137: 12296-12303. PMID: 26352914, DOI: 10.1021/jacs.5b06865.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsP2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy
Wang H, Hong L, Huang J, Jiang Q, Tao R, Tan C, Lu N, Wang C, Ahmed M, Lu Y, Liu Z, Shi W, Lai E, Wilcox C, Han F. P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Research 2015, 25: 674-690. PMID: 25998681, PMCID: PMC4456628, DOI: 10.1038/cr.2015.61.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSeptic encephalopathyLeukocyte adhesionSeptic miceEndothelial ICAM-1 expressionSurvival of septic miceSepsis-induced increaseICAM-1 expressionEndothelial ICAM-1Development of encephalopathyBrain damage in vivoLeukocyte-endothelial adhesionBrain endothelial cellsEarly survivalHypomorphic mutant miceTwo-photon laser scanning microscopyCXCL1 levelsCecal ligationICAM-1Mutant miceNeurovascular protectionNeurovascular injuryDamage in vivoVascular inflammationP2RX7Endothelial cellsValproic Acid Influences MTNR1A Intracellular Trafficking and Signaling in a β-Arrestin 2-Dependent Manner
Hong L, Jiang Q, Long S, Wang H, Zhang L, Tian Y, Wang C, Cao J, Tao R, Huang J, Liao M, Lu Y, Fukunaga K, Zhou N, Han F. Valproic Acid Influences MTNR1A Intracellular Trafficking and Signaling in a β-Arrestin 2-Dependent Manner. Molecular Neurobiology 2015, 53: 1237-1246. PMID: 25613019, DOI: 10.1007/s12035-014-9085-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsbeta-ArrestinsCyclic AMP-Dependent Protein KinasesEndocytosisExtracellular Signal-Regulated MAP KinasesFluorescence Resonance Energy TransferHEK293 CellsHumansIntracellular SpaceMelatoninMicePhosphorylationProtein BindingProtein Transportrab GTP-Binding ProteinsReceptor, Melatonin, MT1Signal TransductionValproic AcidConceptsWhole-cell currentsIntracellular traffickingValproic acidValproate exposureTime-lapse confocal microscopyReceptor subtype 1Internalization kineticsPhosphorylation of PKARisk of autism spectrum disorderEpitope-tagged receptorsNeuro-2a cellsCurrents of cellsVPA treatmentSubtype 1Presence of melatoninMTNR1ALiving cellsNeuro-2aHEK-293TraffickingMelatonin treatmentValproateConfocal microscopyMelatoninB-arrestin
2014
Nitrosative Stress Induces Peroxiredoxin 1 Ubiquitination During Ischemic Insult via E6AP Activation in Endothelial Cells Both In Vitro and In Vivo
Tao R, Wang H, Hong L, Huang J, Lu Y, Liao M, Ye W, Lu N, Zhu D, Huang Q, Fukunaga K, Lou Y, Shoji I, Wilcox C, Lai E, Han F. Nitrosative Stress Induces Peroxiredoxin 1 Ubiquitination During Ischemic Insult via E6AP Activation in Endothelial Cells Both In Vitro and In Vivo. Antioxidants & Redox Signaling 2014, 21: 1-16. PMID: 24295341, PMCID: PMC4048580, DOI: 10.1089/ars.2013.5381.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMiddle cerebral artery occlusionOxygen-glucose deprivationEndothelial cellsIschemic insultE3 ubiquitin ligase E6-associated proteinBlood-brain barrier leakageIn vivoUbiquitin ligase E6-associated proteinProgression of ischemic damageCerebral artery occlusionNitrosative stressCerebral ischemia in vitroIschemia in vitroLentiviral vectorsBrain deliveryRelevant in vivoE6-associated proteinNeurovascular protectionTreatment strategiesArtery occlusionNeuronal damageIschemic damageBarrier leakageCerebral damageFormation of reactive nitrogen species
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