2016
Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells
Xu L, Kittrell S, Yeudall WA, Yang H. Folic acid-decorated polyamidoamine dendrimer mediates selective uptake and high expression of genes in head and neck cancer cells. Nanomedicine 2016, 11: 2959-2973. PMID: 27781559, PMCID: PMC5144492, DOI: 10.2217/nnm-2016-0244.Peer-Reviewed Original ResearchConceptsNeck cancer cellsCancer cellsFR-dependent mannerEnhanced gene expressionGene expressionSame binding siteCellular uptakeGenesDelivery of genesBinding sitesHigh expressionFree FASuitable vectorPlasmidDNA plasmidsCellsTransfection resultsExpressionTransfection efficiencySelective uptakeUptakeFolate receptorHigh levelsVectorFA
2010
Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25‐Hydroxycholesterol and 25‐Hydroxycholesterol‐3‐sulfate
Xu L, Bai Q, Rodriguez‐Agudo D, Hylemon PB, Heuman DM, Pandak WM, Ren S. Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25‐Hydroxycholesterol and 25‐Hydroxycholesterol‐3‐sulfate. Lipids 2010, 45: 821-832. PMID: 20700770, DOI: 10.1007/s11745-010-3451-y.Peer-Reviewed Original ResearchConceptsSREBP-1 protein levelsAcetyl-CoA carboxylase 1Fatty acid synthaseLipid metabolismPromoter-reporter geneProtein levelsImportant regulatory moleculesNFkappaB-dependent genesHepatocyte lipid metabolismLXR/SREBPTarget genesFAS mRNA levelsReporter geneRegulatory moleculesKey enzymeNFkappaB nuclear translocationAcid synthasePrimary rat hepatocytesIkappaBalpha levelsCholesterol biosynthesisNuclear translocationGenesLuciferase activityPotent regulatorNFkappaB activation