2019
Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy
Xu L, Yang H. Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy. Methods In Molecular Biology 2019, 1974: 393-408. PMID: 31099016, DOI: 10.1007/978-1-4939-9220-1_26.BooksConceptsGene therapyGene delivery systemsNeck cancer gene therapyCancer gene therapyDelivery systemNanoparticle carriersGene deliveryDendrimer nanoparticlesHigh biocompatibilityGene transfectionKnockdown efficiencyTumor targetingSuitable platformFolic acidIRDye 800CWSustained retentionGeneration 4DendrimersNanoparticlesBioimagingCarriersBiocompatibilityHereinPlatformPlasmid
2017
Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery
Xu L, Cooper RC, Wang J, Yeudall WA, Yang H. Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery. ACS Biomaterials Science & Engineering 2017, 3: 1641-1653. PMID: 29147682, PMCID: PMC5683721, DOI: 10.1021/acsbiomaterials.7b00166.Peer-Reviewed Original ResearchStrain-promoted azide-alkyne cycloadditionAzide-alkyne cycloadditionDegree of PEGylationCross-linked networkDBCO groupsBioorthogonal chemistryDendrimer generationPEG spacerDrug deliveryChain lengthGeneration 4.0Sustained releaseHigh cytocompatibilityLocal drug deliveryPEG-BALoading densityDibenzocyclooctyneAnticancer drugsHydrogelsPhysical propertiesStructural parametersDendrimersBisazideChemistryCycloaddition
2015
Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug
Zolotarskaya OY, Xu L, Valerie K, Yang H. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Advances 2015, 5: 58600-58608. PMID: 26640689, PMCID: PMC4669072, DOI: 10.1039/c5ra07987j.Peer-Reviewed Original ResearchCamptothecin prodrugEfficient click chemistryAnionic polyamidoamine dendrimersSustained drug deliveryClick synthesisClick chemistryClick reactionCoupling reactionMultifunctional dendrimersFree CPTPolyamidoamine dendrimersReaction efficiencyDrug deliveryMethyl-morpholinium chlorideDendrimersCPT conjugatesSlow releaseDimethyl sulfoxideAgent 4PropargylaminesChemistrySynthesisReactionDose-dependent toxicityHuman glioma cells