Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery
Xu L, Cooper RC, Wang J, Yeudall WA, Yang H. Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery. ACS Biomaterials Science & Engineering 2017, 3: 1641-1653. PMID: 29147682, PMCID: PMC5683721, DOI: 10.1021/acsbiomaterials.7b00166.Peer-Reviewed Original ResearchStrain-promoted azide-alkyne cycloadditionAzide-alkyne cycloadditionDegree of PEGylationCross-linked networkDBCO groupsBioorthogonal chemistryDendrimer generationPEG spacerDrug deliveryChain lengthGeneration 4.0Sustained releaseHigh cytocompatibilityLocal drug deliveryPEG-BALoading densityDibenzocyclooctyneAnticancer drugsHydrogelsPhysical propertiesStructural parametersDendrimersBisazideChemistryCycloaddition