Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug
Zolotarskaya OY, Xu L, Valerie K, Yang H. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Advances 2015, 5: 58600-58608. PMID: 26640689, PMCID: PMC4669072, DOI: 10.1039/c5ra07987j.Peer-Reviewed Original ResearchCamptothecin prodrugEfficient click chemistryAnionic polyamidoamine dendrimersSustained drug deliveryClick synthesisClick chemistryClick reactionCoupling reactionMultifunctional dendrimersFree CPTPolyamidoamine dendrimersReaction efficiencyDrug deliveryMethyl-morpholinium chlorideDendrimersCPT conjugatesSlow releaseDimethyl sulfoxideAgent 4PropargylaminesChemistrySynthesisReactionDose-dependent toxicityHuman glioma cells