2021
The NaVy paradox: reducing sodium currents increases excitability
Kaczmarek LK. The NaVy paradox: reducing sodium currents increases excitability. Trends In Neurosciences 2021, 44: 767-768. PMID: 34373125, PMCID: PMC8813127, DOI: 10.1016/j.tins.2021.07.008.Peer-Reviewed Original Research
2002
HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons
White BH, Cummins TR, Wolf DH, Waxman SG, Russell DS, Kaczmarek LK. HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons. Journal Of Neurophysiology 2002, 87: 2149-2157. PMID: 11929932, DOI: 10.1152/jn.00498.2001.Peer-Reviewed Original ResearchConceptsSodium currentAnti-HSV antibodiesAverage spike frequencyWild-type HSV-1Helper virusViral-based strategiesDays of transductionCultured neuronsHSV-1Spike frequencyGene deliveryNeuronsMammalian neuronsAmplicon systemSimilar suppressionHSV-1 genesVirusTherapeutic purposesViral proteinsAmplicon preparationsCellsCoinfectionSuppressionPreparation resultsTiters
2001
Diversity in the Structure and Function of Ion Channels
B.Levitan I, Kaczmarek L. Diversity in the Structure and Function of Ion Channels. 2001, 139-162. DOI: 10.1093/oso/9780195145236.003.0007.Peer-Reviewed Original ResearchIon channelsGreat diversityDiversityConsiderable diversityRapid membrane depolarizationMembrane depolarizationElectrical activityVoltage-dependent sodium currentsVoltage-dependent potassium currentsAxonal membraneSquid giant axonNeuronal cell bodiesCell bodiesGiant axonsPotassium currentAction potentialsSodium currentMembraneActivityAxons
1990
Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current
Flamm R, Birnberg N, Kaczmarek L. Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current. Pflügers Archiv - European Journal Of Physiology 1990, 416: 120-125. PMID: 2191273, DOI: 10.1007/bf00370232.Peer-Reviewed Original ResearchConceptsTTX-sensitive currentsResistant currentSodium currentTTX-resistant sodium currentsVoltage-dependent sodium currentsSodium channel blocker tetrodotoxinTTX-resistant currentChannel blocker tetrodotoxinAnterior pituitary tumorsVoltage-dependent sodiumCell linesC-Ha-ras geneTTX-sensitiveBlocker tetrodotoxinPituitary tumorsExcitable cell lineC-Ha-ras oncogeneTetrodotoxin sensitivityTetrodotoxinAtT-20 cellsControl cellsCellsRate of inactivationTransfectionTumors
1984
A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
Kaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsCyclic AMP analoguePotassium currentOutward currentsNormal ionic mediumOnset of afterdischargePhosphodiesterase-resistant cAMP analoguePeak inward currentsAMP analogueBag cell clustersDelayed potassium currentMinority of cellsSpontaneous dischargeCalcium currentPeptidergic neuronsVoltage-clamp analysisCell culturesTwo-electrode voltage clampInward currentsSodium currentNegative slope resistanceA-currentMarked reductionNeurons