2018
Blocking Zika virus vertical transmission
Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. Blocking Zika virus vertical transmission. Scientific Reports 2018, 8: 1218. PMID: 29352135, PMCID: PMC5775359, DOI: 10.1038/s41598-018-19526-4.Peer-Reviewed Original ResearchNeural progenitor cellsZika virusViral burdenVertical transmissionSOF treatmentZika virus vertical transmissionAnti-ZIKV activityAntiviral immune responseImmunodeficient mouse modelHuman neural cell typesHuman neural progenitor cellsCell deathNucleotide analog inhibitorBody of evidenceChronic infectionNeural cell typesImmune responseMouse modelCongenital malformationsAnimal modelsVaccine developmentInfected individualsSofosbuvirProgenitor cellsTreatment
2017
Modeling neuro-immune interactions during Zika virus infection
Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, de A. Zanotto PM, Beltrão-Braga PCB, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Human Molecular Genetics 2017, 27: 41-52. PMID: 29048558, PMCID: PMC5886060, DOI: 10.1093/hmg/ddx382.Peer-Reviewed Original ResearchConceptsNeuro-immune interactionsZika virus infectionVirus infectionSerious neurologic complicationsAntiviral immune responsePro-inflammatory responseSimilar pro-inflammatory responsesNeural precursor cellsNew therapeutic drugsZIKV pathologyHepatitis CNeurologic complicationsMicroglia interactionsHuman microgliaImmune responseViral infectionBrazilian ZIKVMicrogliaInfectionNeural cellsTherapeutic drugsBirth defectsPrecursor cellsDrugsHuman tissues