2009
Lessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study
Wackers FJ, Young LH. Lessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study. Journal Of Nuclear Cardiology 2009, 16: 855-859. PMID: 19685266, DOI: 10.1007/s12350-009-9138-1.Commentaries, Editorials and LettersCardiac Outcomes After Screening for Asymptomatic Coronary Artery Disease in Patients With Type 2 Diabetes : The DIAD Study: A Randomized Controlled Trial
Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE, Investigators F. Cardiac Outcomes After Screening for Asymptomatic Coronary Artery Disease in Patients With Type 2 Diabetes : The DIAD Study: A Randomized Controlled Trial. JAMA 2009, 301: 1547-1555. PMID: 19366774, PMCID: PMC2895332, DOI: 10.1001/jama.2009.476.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseType 2 diabetesNonfatal myocardial infarctionAsymptomatic coronary artery diseaseMyocardial perfusion imagingCardiac event rateMyocardial infarctionCardiac deathMPI defectsCardiac outcomesEvent ratesScreened groupArtery diseaseSymptoms of CADRadionuclide myocardial perfusion imagingAsymptomatic Diabetics (DIAD) studyHigh cardiac riskLow event ratesPositive predictive valueDetection of ischemiaPrimary medical preventionCoronary revascularizationDiabetes clinicIdentifies patientsControlled Trials
2007
Screening for Coronary Artery Disease in Patients With Diabetes
Bax JJ, Young LH, Frye RL, Bonow RO, Steinberg HO, Barrett EJ. Screening for Coronary Artery Disease in Patients With Diabetes. Diabetes Care 2007, 30: 2729-2736. PMID: 17901530, DOI: 10.2337/dc07-9927.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAtherosclerosisCoronary DiseaseDiabetic AngiopathiesDiabetic NeuropathiesDiabetic RetinopathyHumansHyperglycemiaMass ScreeningRisk AssessmentConceptsCoronary artery diseaseArtery diseaseCardiovascular diseaseHigh-risk coronary artery diseaseStable coronary artery diseaseCoronary artery calcium scoringAdditive survival benefitIntensive medical managementRecognition of diabetesCVD risk reductionPercutaneous coronary revascularizationStrong clinical suspicionAmerican Diabetes AssociationType 2 diabetesClinical trial resultsCost of diabetesAsymptomatic patientsAtherosclerotic burdenCoronary revascularizationCardiac eventsClinical suspicionCoronary atherosclerosisDiabetic populationSurvival benefitAsymptomatic atherosclerosisResolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. Diabetes Care 2007, 30: 2892-2898. PMID: 17682123, DOI: 10.2337/dc07-1250.Peer-Reviewed Original ResearchConceptsResolution of ischemiaType 2 diabetesDetection of ischemiaNew ischemiaAsymptomatic Diabetics (DIAD) studyCardiovascular risk factorsAsymptomatic myocardial ischemiaAdenosine stress myocardial perfusionRepeat stressIschemia increasesAsymptomatic patientsCardiac eventsMore patientsACE inhibitorsMyocardial ischemiaRisk factorsIntensive treatmentDiabetic studyIschemiaMyocardial perfusionPatientsMedical treatmentDiabetesInitial evaluationGreater increase
2004
Diastolic Function and Type 1 Diabetes
Young LH. Diastolic Function and Type 1 Diabetes. Diabetes Care 2004, 27: 2081-2083. PMID: 15277445, DOI: 10.2337/diacare.27.8.2081.Commentaries, Editorials and LettersBrachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study)
Papaioannou GI, Seip RL, Grey NJ, Katten D, Taylor A, Inzucchi SE, Young LH, Chyun DA, Davey JA, Wackers FJ, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Engel S, Heller GV. Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study). The American Journal Of Cardiology 2004, 94: 294-299. PMID: 15276091, DOI: 10.1016/j.amjcard.2004.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlbuminuriaBrachial ArteryCoronary Artery DiseaseC-Reactive ProteinDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisProspective StudiesReference ValuesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsUltrasonography, DopplerVasoconstrictionVasodilationConceptsEndothelium-independent vasodilationEndothelium-dependent vasodilationBrachial artery reactivityType 2 diabetes mellitusHormone replacement therapyDiabetes mellitusC-reactive proteinSystemic inflammationAsymptomatic patientsEndothelial dysfunctionIndependent predictorsReplacement therapyNovel atherosclerotic risk factorAsymptomatic Diabetics (DIAD) studyAtherosclerotic risk factorsPresence of microalbuminuriaFuture cardiovascular eventsSimilar baseline characteristicsDetection of ischemiaCardiovascular eventsBaseline characteristicsBrachial arteryVascular dysfunctionEntire cohortRisk factorsDetection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects
Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Heller GV, Filipchuk N, Engel S, Ratner RE, Iskandrian AE. Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects. Diabetes Care 2004, 27: 1954-1961. PMID: 15277423, DOI: 10.2337/diacare.27.8.1954.Peer-Reviewed Original ResearchConceptsSilent myocardial ischemiaType 2 diabetesCardiac risk factorsMyocardial ischemiaAsymptomatic patientsSilent ischemiaNormal perfusionRisk factorsTraditional cardiac risk factorsAmerican Diabetes Association guidelinesTomography myocardial perfusion imagingRegional myocardial perfusion abnormalitiesAbnormal stress testAsymptomatic diabetic subjectsAsymptomatic Diabetics (DIAD) studyCurrent American Diabetes AssociationPrevalence of ischemiaCardiac autonomic dysfunctionLarge perfusion defectsST-segment depressionCoronary artery diseaseAmerican Diabetes AssociationMyocardial perfusion abnormalitiesMyocardial perfusion imagingStrongest predictor