1989
Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog
Young L, Zaret B, Barrett E. Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog. Metabolism 1989, 38: 1115-1119. PMID: 2682138, DOI: 10.1016/0026-0495(89)90049-8.Peer-Reviewed Original ResearchConceptsPhysiologic hyperinsulinemiaConscious dogsFree fatty acidsArterial free fatty acid concentrationMumol/minHeart muscleArterial plasma insulinMyocardial lactate uptakeFree fatty acid concentrationsArterial lactate concentrationHyperinsulinemic-euglycemic clampMyocardial glucose uptakeHyperinsulinemia increasesEuglycemic hyperinsulinemiaNormal heart muscleEuglycemic clampFatty acidsPlasma insulinBasal measurementsBlood glucoseLactate extractionFatty acid concentrationsMyocardial uptakeLactate uptakeHyperinsulinemia
1988
Effect of Chronic Diabetes on Myocardial Fuel Metabolism and Insulin Sensitivity
Barrett E, Schwartz R, Young L, Jacob R, Zaret B. Effect of Chronic Diabetes on Myocardial Fuel Metabolism and Insulin Sensitivity. Diabetes 1988, 37: 943-948. PMID: 3290011, DOI: 10.2337/diab.37.7.943.Peer-Reviewed Original ResearchConceptsArterial free fatty acidsFree fatty acidsMyocardial balanceInsulin clampBranched-chain amino acid concentrationsEuglycemic insulin clamp techniqueGlucose uptakeInsulin-induced hypoaminoacidemiaInsulin clamp techniqueInsulin-deficient diabetesPlasma glucose concentrationFuel substrate metabolismSignificant myocardial uptakeEffect of insulinMyocardial fuel metabolismSignificant glucose uptakePhysiologic hyperinsulinemiaBasal periodChronic diabetesDiabetic animalsInsulin sensitivityAcute effectsAdditional dogsAmino acid concentrationsMyocardial uptake