1995
Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance.
McNulty P, Louard R, Deckelbaum L, Zaret B, Young L. Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance. Circulation 1995, 92: 2151-6. PMID: 7554195, DOI: 10.1161/01.cir.92.8.2151.Peer-Reviewed Original ResearchConceptsMyocardial protein degradationInsulin infusionCardiovascular diseaseMyocardial protein synthesisInsulin resistancePhenylalanine balanceMyocardial hypertrophyWhole-body glucose metabolismCoronary artery diseaseIschemic heart diseasePlasma insulin concentrationNet phenylalanine balanceWhole-body carbohydrate metabolismEffect of insulinMyocardial protein metabolismArtery diseaseAcute hyperinsulinemiaProtein synthesisHeart diseaseInsulin concentrationsPlasma concentrationsAntiproteolytic actionHyperinsulinemiaGlucose metabolismConstant infusion
1992
Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart.
Young LH, Dahl DM, Rauner D, Barrett EJ. Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart. Circulation Research 1992, 71: 393-400. PMID: 1628395, DOI: 10.1161/01.res.71.2.393.Peer-Reviewed Original ResearchConceptsMyocardial protein degradationProtein degradationProtein synthesisMyocardial protein turnoverAmino acid replacementsAcid replacementsProtein turnoverEssential amino acidsAmino acidsPhenylalanine balanceAmino acid concentrationsNet myocardial releaseSpecific activityPhenylalanineVivoDegradationAnimalsBasal rateIsotopic steady statePhysiological hyperinsulinemiaTurnover
1991
Myocardial protein turnover in patients with coronary artery disease. Effect of branched chain amino acid infusion.
Young LH, McNulty PH, Morgan C, Deckelbaum LI, Zaret BL, Barrett EJ. Myocardial protein turnover in patients with coronary artery disease. Effect of branched chain amino acid infusion. Journal Of Clinical Investigation 1991, 87: 554-560. PMID: 1991838, PMCID: PMC296343, DOI: 10.1172/jci115030.Peer-Reviewed Original ResearchConceptsBranched-chain amino acid infusionCoronary artery diseaseAmino acid infusionProtein turnoverBCAA infusionProtein synthesisArtery diseaseAcid infusionAmino acidsMyocardial protein turnoverCardiac double productCoronary blood flowPlasma insulin levelsMyocardial oxygen consumptionHuman heartProtein degradationNegative protein balanceEssential amino acidsMyocardial balanceInsulin levelsDouble productPhenylalanine balanceAnabolic effectsMyocardial uptakePostabsorptive patients