2022
122-LB: Effect of Dapagliflozin on Mitochondrial Metabolism and Cardiac Function in the Failing Heart
GOEDEKE L, MA Y, ZHANG J, GUERRERA N, WU X, ZHANG D, KAHN M, ZHANG X, YOUNG L, SHULMAN G. 122-LB: Effect of Dapagliflozin on Mitochondrial Metabolism and Cardiac Function in the Failing Heart. Diabetes 2022, 71 DOI: 10.2337/db22-122-lb.Peer-Reviewed Original ResearchDAPA treatmentLV ejection fractionEjection fractionHeart failureMI ratsCardiac outputMyocardial infarctionCardiac functionLeft ventricularEffect of dapagliflozinMale Sprague-DawleyPlasma glucose concentrationMalonyl-CoA contentMitochondrial oxidationKetone availabilityΒOHB levelsVehicle treatmentPermanent ligationSGLT2 inhibitionSGLT2 inhibitorsCardioprotective effectsCoronary arteryAcetyl-CoA contentFailing HeartMitochondrial metabolism
2018
In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
Boutagy NE, Wu J, Cai Z, Zhang W, Booth CJ, Kyriakides TC, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ. In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents. JACC Basic To Translational Science 2018, 3: 378-390. PMID: 30062224, PMCID: PMC6058999, DOI: 10.1016/j.jacbts.2018.02.003.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSuperoxide productionReactive oxygen speciesMarkers of ROSNovel positron emission tomography (PET) tracerEarly detectionMyocardial superoxide productionVentricular ejection fractionDoxorubicin-induced cardiotoxicityCardiac superoxide productionPositron emission tomography (PET) tracerPositron emission tomographyEmission tomography tracerEjection fractionCancer patientsCardiotoxicity detectionEmission tomographyTomography tracerCardiotoxicityReactive oxygen species (ROS) detectionWeeksOxygen speciesRodentsEchocardiographyPatients
1990
Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty
Young L, Jaffe C, Revkin J, McNulty P, Cleman M. Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty. The American Journal Of Cardiology 1990, 65: 986-990. PMID: 2327360, DOI: 10.1016/0002-9149(90)91001-m.Peer-Reviewed Original ResearchConceptsGreat cardiac veinDistal perfusionLactate releaseEjection fractionVentricular functionCardiac veinBalloon inflationLeft ventricular ejection fractionDistal coronary perfusionMyocardial lactate metabolismVentricular ejection fractionMyocardial lactate releaseRegional contractile functionNet lactate extractionNet lactate releaseCoronary angioplastyLeft anteriorCoronary perfusionLactate extractionContractile functionPerfusionAngioplastyLactate concentrationLactate metabolismOxygenated perfluorocarbon