2022
Efficacy of lower doses of pioglitazone after stroke or transient ischaemic attack in patients with insulin resistance
Spence JD, Viscoli C, Kernan WN, Young LH, Furie K, DeFronzo R, Abdul‐Ghani M, Dandona P, Inzucchi SE. Efficacy of lower doses of pioglitazone after stroke or transient ischaemic attack in patients with insulin resistance. Diabetes Obesity And Metabolism 2022, 24: 1150-1158. PMID: 35253334, DOI: 10.1111/dom.14687.Peer-Reviewed Original ResearchConceptsNew-onset diabetesAdjusted hazard ratioHazard ratioLow dosesAdverse effectsInsulin Resistance InterventionTransient ischemic attackSecondary prevention strategiesAnti-atherosclerotic propertiesInsulin-sensitizing drugsLess adverse effectsIschemic attackStudy drugHeart failureStroke trialsAdverse outcomesInsulin resistancePioglitazonePrevention strategiesHigh dosesResistance InterventionFull doseWeight gainDiabetesPatients
2012
Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study
Tandon S, Wackers F, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH. Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study. Diabetes And Vascular Disease Research 2012, 9: 124-130. PMID: 22228772, DOI: 10.1177/1479164111431470.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesCanadaCardiovascular DiseasesDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansIncidenceKaplan-Meier EstimateMaleMass ScreeningMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSex FactorsTime FactorsUnited StatesConceptsType 2 diabetesMyocardial perfusion imagingCardiovascular outcomesStress myocardial perfusion imagingAsymptomatic Diabetics (DIAD) studyBetter cardiac outcomesHigh-risk womenCoronary artery diseaseHigh-risk menDetection of ischemiaMPI abnormalitiesAsymptomatic patientsAsymptomatic menCardiac eventsCardiac outcomesArtery diseaseAsymptomatic womenAbnormal screeningDiabetic studyPerfusion imagingDIAD studyWomenMenDiabetesOutcomes
2011
SCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY
Tandon S, Bansal S, Inzucchi S, Staib L, Davey J, Chyun D, Young L, Wackers F. SCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY. Journal Of The American College Of Cardiology 2011, 57: e745. DOI: 10.1016/s0735-1097(11)60745-6.Peer-Reviewed Original Research
2007
Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. Diabetes Care 2007, 30: 2892-2898. PMID: 17682123, DOI: 10.2337/dc07-1250.Peer-Reviewed Original ResearchConceptsResolution of ischemiaType 2 diabetesDetection of ischemiaNew ischemiaAsymptomatic Diabetics (DIAD) studyCardiovascular risk factorsAsymptomatic myocardial ischemiaAdenosine stress myocardial perfusionRepeat stressIschemia increasesAsymptomatic patientsCardiac eventsMore patientsACE inhibitorsMyocardial ischemiaRisk factorsIntensive treatmentDiabetic studyIschemiaMyocardial perfusionPatientsMedical treatmentDiabetesInitial evaluationGreater increase
2006
Diabetes Mellitus and Cardiovascular Disease
Chyun DA, Young LH. Diabetes Mellitus and Cardiovascular Disease. Nursing Clinics Of North America 2006, 41: 681-695. PMID: 17059982, DOI: 10.1016/j.cnur.2006.07.007.BooksConceptsCoronary heart diseaseCardiovascular diseaseHeart diseasePeripheral vascular diseaseAcute myocardial infarctionMultiple risk factorsComplex pathophysiologic processHeart failureChronic manifestationsMyocardial infarctionVascular diseaseRisk factorsPathophysiologic processesSudden deathHigh riskType 1DiseaseEarly detectionDiabetesHypertensionMellitusInfarctionStrokeIndividualsPrevention
2005
AMPK – A pivotal rheostat in the control of cardiac metabolism
Miller E, Russell R, Li J, Young L. AMPK – A pivotal rheostat in the control of cardiac metabolism. Drug Discovery Today Disease Mechanisms 2005, 2: 93-100. DOI: 10.1016/j.ddmec.2005.05.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMyocardial stress responseRegulation of AMPKProtein kinaseCentral regulatorStress responseAMPKNon-metabolic actionsCoronary artery diseaseNovel cardioprotective strategiesType 2 diabetesPotential novel approachArtery diseaseCardioprotective strategiesCardiac metabolismMetabolic actionsPossible roleKinaseRheostatRegulatorRegulationMetabolismDiabetesDiseaseHeart Failure and Cardiac Dysfunction in Diabetes
Young L, Russell R, Chyun D. Heart Failure and Cardiac Dysfunction in Diabetes. Contemporary Cardiology 2005, 555-578. DOI: 10.1385/1-59259-908-7:555.Peer-Reviewed Original ResearchType 2 diabetesHeart failureHigh cardiovascular morbidityPresence of diabetesOral hypoglycemic agentsAge-adjusted riskImpact of diabetesFramingham Heart StudyNondiabetic patientsCardiovascular morbidityNondiabetic menPatient yearsOlder patientsSuch patientsCardiac dysfunctionHypoglycemic agentsHeart StudyClinical problemPatientsDiabetesType 1IncidenceRiskFailureMorbidity
2003
Diagnosis of CAD in patients with diabetes: Who to evaluate
Young LH, Jose P, Chyun D. Diagnosis of CAD in patients with diabetes: Who to evaluate. Current Diabetes Reports 2003, 3: 19-27. PMID: 12643142, DOI: 10.1007/s11892-003-0048-3.BooksConceptsCoronary artery diseaseCardiac testingDiabetic patientsDiagnosis of CADNoninvasive cardiac testingManagement of patientsCAD screeningAsymptomatic ischemiaAsymptomatic patientsSymptomatic patientsArtery diseaseCardiac catheterizationRisk stratificationPatientsAccurate diagnosisDiagnosisAppropriate useDiabetesEffective diagnosisCurrent controversiesRecent informationRevascularizationCatheterizationIschemiaClinicians