2023
Impact of school‐supervised ultra‐long‐acting basal insulin injections on ketosis in youth with T1D and elevated haemoglobin A1c: A pilot study
Nally L, Sherr J, Tichy E, Weyman K, Urban A, Shabanova V, McCollum S, Steffen A, Tamborlane W, Van Name M. Impact of school‐supervised ultra‐long‐acting basal insulin injections on ketosis in youth with T1D and elevated haemoglobin A1c: A pilot study. Diabetic Medicine 2023, 40: e15123. PMID: 37078999, PMCID: PMC10524154, DOI: 10.1111/dme.15123.Peer-Reviewed Original ResearchConceptsBasal insulin injectionsDiabetic ketoacidosisPercent of participantsBlood β-hydroxybutyrateInsulin injectionsBasal insulin dosesBasal insulin typeType 1 diabetesManagement of youthDegludec groupSignificant ketosisAcute complicationsBasal insulinInsulin dosesRisk of ketosisInjected insulinHigher hemoglobinInsulin administrationElevated hemoglobinInsulin typeKetone levelsHigh riskSchool nursesDegludecLarger sample size
2022
Navigating barriers to affording and obtaining insulin and diabetes supplies
Wilcox A, Lipska K, Weinzimer S, Gujral J, Arakaki A, Kerandi L, Nally L. Navigating barriers to affording and obtaining insulin and diabetes supplies. Journal Of Diabetes 2022, 15: 71-75. PMID: 36562281, PMCID: PMC9870729, DOI: 10.1111/1753-0407.13344.Peer-Reviewed Original Research
2020
A Pilot Study of Youth With Type 1 Diabetes Initiating Use of a Hybrid Closed-Loop System While Receiving a Behavioral Economics Intervention
Nally LM, Wagner J, Sherr J, Tichy E, Weyman K, Ginley MK, Zajac K, Desousa M, Shabanova V, Petry NM, Tamborlane WV, Van Name M. A Pilot Study of Youth With Type 1 Diabetes Initiating Use of a Hybrid Closed-Loop System While Receiving a Behavioral Economics Intervention. Endocrine Practice 2020, 27: 545-551. PMID: 34120699, PMCID: PMC8206518, DOI: 10.1016/j.eprac.2020.11.017.Peer-Reviewed Original ResearchExpensive Insulin—The Epicenter of a Large, Life-Threatening Problem
Nally LM, Lipska KJ. Expensive Insulin—The Epicenter of a Large, Life-Threatening Problem. JAMA Internal Medicine 2020, 180: 931-933. PMID: 32478822, DOI: 10.1001/jamainternmed.2020.1299.Peer-Reviewed Original Research
2019
Feasibility Studies of an Insulin-Only Bionic Pancreas in a Home-Use Setting
Ekhlaspour L, Nally LM, El-Khatib FH, Ly TT, Clinton P, Frank E, Tanenbaum ML, Hanes SJ, Selagamsetty RR, Hood K, Damiano ER, Buckingham BA. Feasibility Studies of an Insulin-Only Bionic Pancreas in a Home-Use Setting. Journal Of Diabetes Science And Technology 2019, 13: 1001-1007. PMID: 31470740, PMCID: PMC6835195, DOI: 10.1177/1932296819872225.Peer-Reviewed Original ResearchConceptsUsual care armStudy armsOpen-label non-randomized studyHome-use settingDaily insulin doseNon-randomized studiesCare armUsual careInsulin doseIncreased riskMean ageDiabetes burdenGlycemic outcomesHypoglycemic riskIntervention periodAverage glucoseBody weightConsecutive weeksBionic pancreasDynamic glucoseSignificant differencesDlInsulinFactor testingRisk
2015
Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice
Li R, Buras E, Lee J, Liu R, Liu V, Espiritu C, Ozer K, Thompson B, Nally L, Yuan G, Oka K, Chang B, Samson S, Yechoor V, Chan L. Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice. Gene Therapy 2015, 22: 876-882. PMID: 26172077, PMCID: PMC4636470, DOI: 10.1038/gt.2015.62.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsBasic Helix-Loop-Helix Transcription FactorsBetacellulinDiabetes Mellitus, ExperimentalFemaleGenetic TherapyImmunosuppression TherapyInsulinIslets of LangerhansIslets of Langerhans TransplantationLiverMiceMice, Inbred NODNerve Tissue ProteinsSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling ProteinsConceptsSuppressor of cytokine signaling 1NOD miceGene therapyModel of autoimmune diabetesDiabetic miceLineage-defining transcription factorsGlucose-stimulated insulin secretionHelper-dependent adenovirusActivated T cellsLong-term reversal of diabetesRat insulin promoterReversal of diabetesShortage of donor isletsIslet neogenesisOverexpression suppressorIslet growth factorsNeo-isletsType 1 diabetesCytokine signaling 1Transcription factorsTransfer diabetesNon-obeseTreated mice liverAutoimmune diabetesT cells