2018
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A
Burgess EJ, Hoyt LR, Randall MJ, Mank MM, Bivona JJ, Eisenhauer PL, Botten JW, Ballif BA, Lam YW, Wargo MJ, Boyson JE, Ather JL, Poynter ME. Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A. The Journal Of Immunology 2018, 201: 2377-2384. PMID: 30158125, PMCID: PMC6179936, DOI: 10.4049/jimmunol.1800503.Peer-Reviewed Original ResearchConceptsEukaryotic cellsBacterial proteinsSerum amyloid ANumerous bacterial proteinsProteomic analysisMouse cellsRecombinant proteinsBacterial lipoproteinsProteinRecombinant serum amyloid ASAA1 proteinProinflammatory cytokine productionProduction of TNFCytokine productionProinflammatory functionsAmyloid ASerum amyloidCellsLipoprotein lipaseLipoproteinFuture studiesDifferentiationEscherichiaBindingLipopeptides
2017
Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome
Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME. Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. Redox Biology 2017, 12: 883-896. PMID: 28463821, PMCID: PMC5413213, DOI: 10.1016/j.redox.2017.04.020.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureEthanol exposureNLRP3 inflammasomeInflammasome activationPro-inflammatory cytokines IL-1βHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsLong-term ethanol exposureInflammation-linked diseasesNLRP3 inflammasome hyperactivationAberrant NLRP3 inflammasome activationBlood mononuclear cellsExposure of leukocytesCytokines IL-1βNLRP3 inflammasome activationIL-1β secretionNO scavenger carboxy-PTIOAlcohol use disorderMetabolism of ethanolScavenger carboxy-PTIOMouse macrophage cell lineIL-18IL-1βMononuclear cellsProlonged administration