2023
The Effects of Pregnancy on the Pulmonary Immune Response in a Mouse Model of LPS-Induced Acute Lung Injury
Rieck R, Bivona J, Hoyt L, Ventrone S, Kokoszynska M, Bonney E, Suratt B. The Effects of Pregnancy on the Pulmonary Immune Response in a Mouse Model of LPS-Induced Acute Lung Injury. American Journal Of Perinatology 2023, 40: 817-824. PMID: 36796402, DOI: 10.1055/s-0043-1761916.Peer-Reviewed Original ResearchConceptsAcute lung injuryEffect of pregnancyNonpregnant miceAdhesion molecule-1Lung injuryPregnant miceNeutrophil responseImmune responseVCAM-1Mouse modelBronchoalveolar lavage fluid (BALF) differential cell countMolecule-1LPS-Induced Acute Lung InjuryPulmonary innate immune responseVascular cell adhesion molecule-1Intercellular adhesion molecule-1Cell adhesion molecule-1BALF total cellsBlood neutrophil responsesInhalation of lipopolysaccharidePulmonary immune responseVascular endothelial adhesion moleculesSevere lung diseasePeripheral blood neutrophilsBone marrow neutrophils
2022
Ketone body augmentation decreases methacholine hyperresponsiveness in mouse models of allergic asthma
Mank M, Reed L, Fastiggi V, Peña-García P, Hoyt L, Van Der Vliet K, Ather J, Poynter M. Ketone body augmentation decreases methacholine hyperresponsiveness in mouse models of allergic asthma. Journal Of Allergy And Clinical Immunology Global 2022, 1: 282-298. PMID: 36466740, PMCID: PMC9718535, DOI: 10.1016/j.jacig.2022.08.001.Peer-Reviewed Original ResearchKetone ester supplementationMethacholine hyperresponsivenessAllergic asthmaAirway epithelial cellsKetogenic dietDose-dependent mannerKetone bodiesMouse modelElicit anti-inflammatory activityAllergic asthmatic individualsBronchial smooth muscle cellsChronic allergic asthmaHuman airway epithelial cellsEpithelial cellsProinflammatory cytokine secretionIL-8 secretionAnti-inflammatory activityBHB concentrationsSmooth muscle cellsKetone body precursorsRange of mildHDM sensitizationObese asthmaCell typesCorticosteroid treatment
2021
Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations
Gertie JA, Zhang B, Liu EG, Hoyt LR, Yin X, Xu L, Long LL, Soldatenko A, Gowthaman U, Williams A, Eisenbarth SC. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations. Journal Of Allergy And Clinical Immunology 2021, 149: 262-274. PMID: 34051223, PMCID: PMC8626534, DOI: 10.1016/j.jaci.2021.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsArachisDisease Models, AnimalFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsIntestinal MucosaMaleMice, Inbred C3HMice, Inbred C57BLMutationPassive Cutaneous AnaphylaxisPeanut HypersensitivityPermeabilitySpecies SpecificityToll-Like Receptor 4ConceptsC3H/HeJ miceGut permeabilityHeJ miceOral anaphylaxisPeanut challengeFood allergyMouse modelToll-like receptor 4BALB/c miceCytokinesis 8 (DOCK8) mutationsEnhanced gut permeabilityOral peanut challengesDOCK8 functionIngested allergenImmunologic mechanismsAnaphylaxis responsesImmunologic pathwaysAllergic diseasesC57BL/6 micePeanut allergyAntibody responseC miceReceptor 4DOCK8 mutationsIntraperitoneal challenge
2016
Uricase Inhibits Nitrogen Dioxide–Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism
Ather JL, Burgess EJ, Hoyt LR, Randall MJ, Mandal MK, Matthews DE, Boyson JE, Poynter ME. Uricase Inhibits Nitrogen Dioxide–Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism. The Journal Of Immunology 2016, 197: 1720-1732. PMID: 27465529, PMCID: PMC4992621, DOI: 10.4049/jimmunol.1600336.Peer-Reviewed Original ResearchConceptsAllergic airway diseaseAllergic sensitizationAirway diseaseUric acidDevelopment of OVAOVA-specific responsesAirways of miceUric acid levelsAdaptive immune responsesOVA-specific AbT cell proliferationPowerful inhibitory effectEnvironmental air pollutantsImmune deviationOVA challengeOVA uptakeDendritic cellsCytokine productionAdjuvant activityImmune responseRespiratory diseaseMouse modelUric acid formationInhibitory effectAcid levelsWeight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma
Ather JL, Chung M, Hoyt LR, Randall MJ, Georgsdottir A, Daphtary NA, Aliyeva MI, Suratt BT, Bates JH, Irvin CG, Russell SR, Forgione PM, Dixon AE, Poynter ME. Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma. American Journal Of Respiratory Cell And Molecular Biology 2016, 55: 176-187. PMID: 27064658, PMCID: PMC4979374, DOI: 10.1165/rcmb.2016-0070oc.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossObese asthmaMethacholine hyperresponsivenessWeight lossAsthma phenotypesMouse modelBariatric surgery-induced weight lossSurgery-induced weight lossFirmicutes/Bacteroidetes ratioAllergic asthma phenotypeDietary weight lossObese-asthma phenotypeSurgical weight lossSuccessful weight lossElevated proinflammatory cytokinesCentral airway resistanceDiet-induced obesityEnvironmental allergen exposureAdaptive immune responsesSubstantial weight lossDistinct anatomical compartmentsMethacholine responsivenessAllergic asthmaAllergen exposureAsthma symptoms
2015
Anti-Inflammatory Effects of Levalbuterol-Induced 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Airway Epithelial Cells
Randall MJ, Kostin SF, Burgess EJ, Hoyt LR, Ather JL, Lundblad LK, Poynter ME. Anti-Inflammatory Effects of Levalbuterol-Induced 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Airway Epithelial Cells. Frontiers In Endocrinology 2015, 5: 236. PMID: 25628603, PMCID: PMC4290686, DOI: 10.3389/fendo.2014.00236.Peer-Reviewed Original ResearchAirway epithelial cellsPro-inflammatory cytokine productionNF-κB activationAsthmatic subjectsCytokine productionRacemic albuterolEpithelial cellsEpithelial NF-κB activationAnti-inflammatory effectsNF-κB transcriptional activityTumor necrosis factorType 1 activityNF-κB activityAirway inflammationAllergic asthmaEndogenous glucocorticoidsLung functionCombination therapyNecrosis factorCorticosteroidsLuc activityAugments expressionAlbuterolMouse modelNF-κB