Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation
Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME. Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation. The Journal Of Immunology 2016, 197: 1322-1334. PMID: 27421477, PMCID: PMC4975963, DOI: 10.4049/jimmunol.1600406.Peer-Reviewed Original ResearchConceptsTyrosine phosphorylationPattern recognition receptor complexTyrosine phosphatase inhibitor sodiumPhosphatase inhibitor sodiumCellular tyrosine phosphorylationNLRP3 inflammasome activationApical eventsNLRP3 inflammasomeProtein tyrosineMouse macrophage cell lineCARD (ASC) speck formationApoptosis-associated speck-like proteinMacrophage cell lineIL-1βInflammasome activationSpeck-like proteinReceptor complexMouse bone marrow-derived dendritic cellsBone marrow-derived dendritic cellsPhosphorylationMarrow-derived dendritic cellsProinflammatory cytokines IL-1βCell linesInhibitory effectCaspase-1 cleavage