Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome
Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME. Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. Redox Biology 2017, 12: 883-896. PMID: 28463821, PMCID: PMC5413213, DOI: 10.1016/j.redox.2017.04.020.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureEthanol exposureNLRP3 inflammasomeInflammasome activationPro-inflammatory cytokines IL-1βHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsLong-term ethanol exposureInflammation-linked diseasesNLRP3 inflammasome hyperactivationAberrant NLRP3 inflammasome activationBlood mononuclear cellsExposure of leukocytesCytokines IL-1βNLRP3 inflammasome activationIL-1β secretionNO scavenger carboxy-PTIOAlcohol use disorderMetabolism of ethanolScavenger carboxy-PTIOMouse macrophage cell lineIL-18IL-1βMononuclear cellsProlonged administration