Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma
Ather JL, Chung M, Hoyt LR, Randall MJ, Georgsdottir A, Daphtary NA, Aliyeva MI, Suratt BT, Bates JH, Irvin CG, Russell SR, Forgione PM, Dixon AE, Poynter ME. Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma. American Journal Of Respiratory Cell And Molecular Biology 2016, 55: 176-187. PMID: 27064658, PMCID: PMC4979374, DOI: 10.1165/rcmb.2016-0070oc.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossObese asthmaMethacholine hyperresponsivenessWeight lossAsthma phenotypesMouse modelBariatric surgery-induced weight lossSurgery-induced weight lossFirmicutes/Bacteroidetes ratioAllergic asthma phenotypeDietary weight lossObese-asthma phenotypeSurgical weight lossSuccessful weight lossElevated proinflammatory cytokinesCentral airway resistanceDiet-induced obesityEnvironmental allergen exposureAdaptive immune responsesSubstantial weight lossDistinct anatomical compartmentsMethacholine responsivenessAllergic asthmaAllergen exposureAsthma symptoms