2013
Novel Functional Assay for Spindle-Assembly Checkpoint by Cyclin-Dependent Kinase Activity to Predict Taxane Chemosensitivity in Breast Tumor Patient
Torikoshi Y, Gohda K, Davis ML, Symmans WF, Pusztai L, Kazansky A, Nakayama S, Yoshida T, Matsushima T, Hortobagyi GN, Ishihara H, Kim SJ, Noguchi S, Ueno NT. Novel Functional Assay for Spindle-Assembly Checkpoint by Cyclin-Dependent Kinase Activity to Predict Taxane Chemosensitivity in Breast Tumor Patient. Journal Of Cancer 2013, 4: 697-702. PMID: 24312139, PMCID: PMC3842438, DOI: 10.7150/jca.6248.Peer-Reviewed Original ResearchTaxane-containing chemotherapyClinical responsePreoperative chemotherapyTaxane-induced cell deathAnthracycline-based treatmentFine-needle aspiration biopsyLarge prospective studiesBreast cancer patientsCyclin-dependent kinase 1Taxane-resistant tumorsLogistic regression analysisTaxane-containing therapyBreast tumor patientsDysfunction groupTaxane therapyPathologic responseProspective studyCancer patientsPredictive biomarkersTumor patientsBreast cancerClinicopathologic parametersAspiration biopsyBiopsy samplesPatients
2007
Identification of predictive markers to differentiate ixabepilone from paclitaxel activity in ER-negative breast cancer patients
Wu S, Chasalow S, Lee H, Xu L, Paul B, Mokliatchouk O, Symmans W, Zerba K, Pusztai L, Clark E. Identification of predictive markers to differentiate ixabepilone from paclitaxel activity in ER-negative breast cancer patients. Journal Of Clinical Oncology 2007, 25: 2525-2525. DOI: 10.1200/jco.2007.25.18_suppl.2525.Peer-Reviewed Original ResearchBreast cancer patientsER patientsCancer patientsPredictive markerClinical trialsPaclitaxel activityER-negative breast cancer patientsComplete pathological responseER-negative patientsTaxane-containing regimensTaxane-containing therapyExpression levelsIxabepilone treatmentPatient selectionBC patientsPathological responseIxabepilonePatientsTherapeutic valueProtein 3SiRNA studiesDifferential markersROC curveTrialsCandidate markers