2019
Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives
Hung S, Mohan A, Reckhow DA, Godri Pollitt KJ. Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives. Chemosphere 2019, 234: 902-908. PMID: 31519098, DOI: 10.1016/j.chemosphere.2019.06.086.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesNormal human colon cellsHuman liver cancer cellsConcentration-dependent decreaseLiver cancer cellsIntracellular reactive oxygen speciesHuman colon cellsStudy designCell culture mediumCancer cellsColon cellsROS productionCulture mediumGreater cytotoxicityCell linesAcute cytotoxicityCell viabilityToxicological profileToxicological studiesCytotoxicityToxicityEnhanced toxicityOxygen speciesCell mediumPotential underestimation
2017
Comparative Cytotoxicity of Six Iodinated Disinfection Byproducts on Nontransformed Epithelial Human Colon Cells
Sayess R, Khalil A, Shah M, Reckhow D, Pollitt K. Comparative Cytotoxicity of Six Iodinated Disinfection Byproducts on Nontransformed Epithelial Human Colon Cells. Environmental Science & Technology Letters 2017, 4: 143-148. DOI: 10.1021/acs.estlett.7b00064.Peer-Reviewed Original ResearchBromoiodoacetic acidNormal human colon epithelial cellsIodoacetic acidHuman colon epithelial cellsChinese hamster ovary cellsHuman colon cellsColon epithelial cellsTimes more cytotoxicHamster ovary cellsDiiodoacetic acidCHO cellsColon cellsMore cytotoxicOvary cellsEpithelial cellsCellsComparative cytotoxicity