2015
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Kocerha J, Dwivedi Y, Brennand K. Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease. Molecular Psychiatry 2015, 20: 677-684. PMID: 25824307, PMCID: PMC4440836, DOI: 10.1038/mp.2015.30.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCognition DisordersHumansMental DisordersNervous System DiseasesRNA, UntranslatedConceptsPsychiatric diseasesPost-genome sequencing eraNew epigenetic targetsPotent epigenetic regulatorHuman Genome ProjectAttractive therapeutic potentialMicroRNA (miRNA) classNcRNA classesMajor neuronal pathwaysEpigenetic regulatorsSequencing eraEpigenetic targetsNoncoding RNAsGenome ProjectNeuronal pathwaysMultifactorial originPsychiatric disordersSingle proteinTherapeutic potentialReported rolesTherapeutic investigationsPleiotropic capacitySingle neuronsNeurobehavioral phenotypesDiseaseA guide to generating and using hiPSC derived NPCs for the study of neurological diseases.
Topol A, Tran N, Brennand K. A guide to generating and using hiPSC derived NPCs for the study of neurological diseases. Journal Of Visualized Experiments 2015, e52495. PMID: 25742222, PMCID: PMC4354663, DOI: 10.3791/52495.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCytological TechniquesHumansInduced Pluripotent Stem CellsNervous System DiseasesNeural Stem CellsConceptsNeural progenitor cellsHiPSC neural progenitor cellsRapid genetic screeningPluripotent stem cellsCellular phenotypesDevelopmental eventsMolecular consequencesGene expressionNeurological diseasesFunctional neuronsStem cellsProgenitor cellsOnset of symptomsMolecular factorsFurther differentiationPost-mortem studiesDisease initiationGenetic screeningOxidative stressSymptom onsetDisease progressionHealthy controlsDiseaseCellsPatients
2013
Neural stem and progenitor cells in health and disease
Ladran I, Tran N, Topol A, Brennand K. Neural stem and progenitor cells in health and disease. WIREs Mechanisms Of Disease 2013, 5: 701-715. PMID: 24068527, PMCID: PMC4160040, DOI: 10.1002/wsbm.1239.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsAstrocytesCell DifferentiationHumansModels, NeurologicalNervous System DiseasesNeural Stem CellsNeuronsOligodendroglia
2011
Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises
Marchetto M, Brennand K, Boyer L, Gage F. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Human Molecular Genetics 2011, 20: r109-r115. PMID: 21828073, PMCID: PMC4447776, DOI: 10.1093/hmg/ddr336.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsHumansInduced Pluripotent Stem CellsModels, BiologicalNervous System DiseasesNeurons