2017
Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nature Communications 2017, 8: 15157. PMID: 28462912, PMCID: PMC5418582, DOI: 10.1038/ncomms15157.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBrainCell MovementEmbryo, MammalianEthanolFemaleGene Expression Regulation, DevelopmentalHeat Shock Transcription FactorsHumansHydrogen PeroxideInjections, IntraperitonealMaleMaternal ExposureMiceMice, TransgenicNeural Stem CellsNeuronsPhenotypePregnancyPrenatal Exposure Delayed EffectsPrimary Cell CultureSignal Transduction
2014
Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders
Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders. Neuron 2014, 82: 560-572. PMID: 24726381, PMCID: PMC4051437, DOI: 10.1016/j.neuron.2014.03.002.Peer-Reviewed Original ResearchConceptsCerebral cortical cellsHuman neural progenitor cellsNeural progenitor cellsHeat shock factor 1Maternal seizuresSeizure susceptibilityPrenatal exposureNeuropsychiatric dysfunctionShock factor 1Neuronal responsesBrain cellsSchizophrenia patientsBrain disordersLate onsetMouse cortexStructural abnormalitiesNeuropsychiatric disordersHSF1 deficiencyExposure of embryosProgenitor cellsSubthreshold levelsFactor 1Induced pluripotent stem cellsEnvironmental insultsCortical cells