2017
MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice
Mitchell A, Javidfar B, Pothula V, Ibi D, Shen E, Peter C, Bicks L, Fehr T, Jiang Y, Brennand K, Neve R, Gonzalez-Maeso J, Akbarian S. MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice. Molecular Psychiatry 2017, 23: 123-132. PMID: 28115742, PMCID: PMC5966823, DOI: 10.1038/mp.2016.254.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainChromatin ImmunoprecipitationCognition DisordersComputational BiologyDisease Models, AnimalEpigenomicsGene Expression RegulationGreen Fluorescent ProteinsHistonesMEF2 Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeuronsPolymorphism, Single NucleotideSchizophreniaTransduction, GeneticConceptsTherapeutic potentialPrefrontal projection neuronsNeuron-specific promoterUnexplored therapeutic potentialProjection neuronsDrug challengeDisease casesRelated disordersRisk architecturePrefrontal cortexSchizophreniaSingle nucleotide polymorphismsCognitive performancePsychiatric Genomics ConsortiumNeuronal genomeH3K4 hypermethylationRisk lociCognitive enhancement
2008
Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics
Szotek P, Chang H, Brennand K, Fujino A, Pieretti-Vanmarcke R, Celso C, Dombkowski D, Preffer F, Cohen K, Teixeira J, Donahoe P. Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 12469-12473. PMID: 18711140, PMCID: PMC2527935, DOI: 10.1073/pnas.0805012105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBromodeoxyuridineCell ProliferationEpithelial CellsEstrous CycleFemaleGreen Fluorescent ProteinsMiceOvaryRegenerationStem CellsConceptsLabel-retaining cell populationStem/progenitor cellsSomatic stem/progenitor cellsEpithelial label-retaining cellsCoelomic epitheliumProgenitor cellsCell populationsCell-mediated processStem/progenitor cell characteristicsLabel-retaining cellsEstrous cyclingAdult miceProgenitor cell characteristicsMouse ovariesCytoprotective mechanismsSide population
2007
All β Cells Contribute Equally to Islet Growth and Maintenance
Brennand K, Huangfu D, Melton D. All β Cells Contribute Equally to Islet Growth and Maintenance. PLOS Biology 2007, 5: e163. PMID: 17535113, PMCID: PMC1877817, DOI: 10.1371/journal.pbio.0050163.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCell DifferentiationCell ProliferationFemaleGenes, ReporterGenetic MarkersGreen Fluorescent ProteinsHistonesIn Vitro TechniquesInsulin-Secreting CellsIslets of LangerhansMaleMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalMosaicismRecombinant Fusion ProteinsTetracyclineConceptsBeta-cell populationBeta cellsBeta-cell replicationHealthy adult miceBeta-cell poolCell populationsDifferentiated beta cellsStem cellsReplacement therapyCell replacement therapyAdult miceIslet growthΒ-cellsProtein expressionCell poolReplicative capacityCell replicationHepatocyte populationAdult stem cellsClonal analysisCellsLevel of fluorescenceFluorescent protein expressionPopulationDiabetes