2016
Spatial genome organization and cognition
Rajarajan P, Gil S, Brennand K, Akbarian S. Spatial genome organization and cognition. Nature Reviews Neuroscience 2016, 17: 681-691. PMID: 27708356, PMCID: PMC5503467, DOI: 10.1038/nrn.2016.124.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCognitionDNA MethylationDNA-Binding ProteinsGenomeHumansNeurodevelopmental DisordersNeuronsRNA, UntranslatedConceptsPromoter-enhancer interactionsRegulatory sequencesGene transcription start siteSpatial genome organizationNon-coding DNACis-regulatory sequencesHundreds of kilobasesTranscription start siteCRISPR-Cas systemsChromosomal loopingGenome organizationTranscriptional activatorChromosomal conformationCohesin complexGenetic risk architectureTranscriptional regulationStart siteCandidate genesGene expressionStructural variantsDecoy modelsNeurodevelopmental diseasesCrucial layerEditing techniquesProgenitor cells
2015
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Kocerha J, Dwivedi Y, Brennand K. Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease. Molecular Psychiatry 2015, 20: 677-684. PMID: 25824307, PMCID: PMC4440836, DOI: 10.1038/mp.2015.30.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCognition DisordersHumansMental DisordersNervous System DiseasesRNA, UntranslatedConceptsPsychiatric diseasesPost-genome sequencing eraNew epigenetic targetsPotent epigenetic regulatorHuman Genome ProjectAttractive therapeutic potentialMicroRNA (miRNA) classNcRNA classesMajor neuronal pathwaysEpigenetic regulatorsSequencing eraEpigenetic targetsNoncoding RNAsGenome ProjectNeuronal pathwaysMultifactorial originPsychiatric disordersSingle proteinTherapeutic potentialReported rolesTherapeutic investigationsPleiotropic capacitySingle neuronsNeurobehavioral phenotypesDisease