2017
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature Genetics 2017, 49: 1239-1250. PMID: 28671686, PMCID: PMC5560095, DOI: 10.1038/ng.3906.Peer-Reviewed Original ResearchIn utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain
Chatterton Z, Hartley B, Seok M, Mendelev N, Chen S, Milekic M, Rosoklija G, Stankov A, Trencevsja-Ivanovska I, Brennand K, Ge Y, Dwork A, Haghighi F. In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. Epigenetics & Chromatin 2017, 10: 4. PMID: 28149327, PMCID: PMC5270321, DOI: 10.1186/s13072-017-0111-y.Peer-Reviewed Original ResearchMeSH KeywordsBrainDNA MethylationFemaleFetal DevelopmentFetusGestational AgeGTP-Binding Protein alpha Subunits, Gq-G11HumansImmunohistochemistryInduced Pluripotent Stem CellsMaleMaternal ExposureNeural Stem CellsNeuronsPregnancyPregnancy Trimester, SecondPromoter Regions, GeneticSmokingSuccinate DehydrogenaseTubulinConceptsMaternal smokingDorsolateral prefrontal cortexNeuronal contentCortical gray matterFetal brain growthDifferentiation of neuronsBehavioral problemsFalse discovery correctionSignificant DMRsSmoking exposureGestational ageSecond trimesterUtero exposurePrenatal exposureCortical developmentFetal brainExposure altersSmokingBrain growthGray matterCell proportionFetusesPrefrontal cortexDNA methylationMethylation profiles
2016
Spatial genome organization and cognition
Rajarajan P, Gil S, Brennand K, Akbarian S. Spatial genome organization and cognition. Nature Reviews Neuroscience 2016, 17: 681-691. PMID: 27708356, PMCID: PMC5503467, DOI: 10.1038/nrn.2016.124.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCognitionDNA MethylationDNA-Binding ProteinsGenomeHumansNeurodevelopmental DisordersNeuronsRNA, UntranslatedConceptsPromoter-enhancer interactionsRegulatory sequencesGene transcription start siteSpatial genome organizationNon-coding DNACis-regulatory sequencesHundreds of kilobasesTranscription start siteCRISPR-Cas systemsChromosomal loopingGenome organizationTranscriptional activatorChromosomal conformationCohesin complexGenetic risk architectureTranscriptional regulationStart siteCandidate genesGene expressionStructural variantsDecoy modelsNeurodevelopmental diseasesCrucial layerEditing techniquesProgenitor cells