2015
Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells
Ho S, Hartley B, Julia T, Beaumont M, Stafford K, Slesinger P, Brennand K. Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells. Methods 2015, 101: 113-124. PMID: 26626326, PMCID: PMC4860098, DOI: 10.1016/j.ymeth.2015.11.019.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cellsNeural progenitor cellsHiPSC-derived neural progenitor cellsHigh-throughput drug screeningHiPSC neural progenitor cellsExogenous transcription factorsProgenitor cellsInduced pluripotent stem cellsPatient-specific platformPluripotent stem cellsPatient-derived neuronsSomatic reprogrammingTranscription factorsGenetic variationExcitatory neuronsDrug screeningNeurogenin 2Neuronal inductionFunctional neuronsThroughput drug screeningNeuronal phenotypeLentiviral transductionStem cellsStarting populationDisease etiology
2008
Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells
Stadtfeld M, Brennand K, Hochedlinger K. Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells. Current Biology 2008, 18: 890-894. PMID: 18501604, PMCID: PMC2819222, DOI: 10.1016/j.cub.2008.05.010.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsPluripotent stem cellsCell typesIPS cellsStem cellsC-MycTranscription factors Oct4Rare cell typesInduced pluripotent stem cellsCertain cell typesAdult stem cellsInducible lentivirusVitro reprogrammingFactors OCT4Pluripotent cellsEctopic expressionGenetic proofPancreatic β-cellsGerm layersDifferentiated cellsChimeric animalsPluripotency markersDifferentiation stageBeta cellsPancreatic beta cells