2021
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Powell SK, O’Shea C, Townsley K, Prytkova I, Dobrindt K, Elahi R, Iskhakova M, Lambert T, Valada A, Liao W, Ho SM, Slesinger PA, Huckins LM, Akbarian S, Brennand KJ. Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk. Molecular Psychiatry 2021, 28: 1970-1982. PMID: 34493831, PMCID: PMC8898985, DOI: 10.1038/s41380-021-01273-0.Peer-Reviewed Original ResearchConceptsInduced dopaminergic neuronsDopaminergic neuronsMidbrain dopaminergic neuron developmentNeuron identityHuman induced pluripotent stem cellsCannabis use disorderDopaminergic neuron developmentAction potential durationGlutamatergic neuronsDopamine synthesisSpontaneous burstsPotential durationUse disordersNeuronal subtypesPsychiatric diseasesBipolar disorderElectrophysiological propertiesDisease riskHyperpolarization potentialPsychiatric disease riskNeuron developmentOscillatory activityNeuronsHeterogenous cell populationsCell populations
2020
Pluripotent Stem Cells May Unlock How Genetic Variants Result in Mental Disorders
Powell S, Yu A, Katz C, Brennand K. Pluripotent Stem Cells May Unlock How Genetic Variants Result in Mental Disorders. Psychiatric News 2020, 55 DOI: 10.1176/appi.pn.2020.7b14.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsA psychiatric disease-related circular RNA controls synaptic gene expression and cognition
Zimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell’Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, Perrone-Bizzozero N, Brigman JL, Mellios N. A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Molecular Psychiatry 2020, 25: 2712-2727. PMID: 31988434, PMCID: PMC7577899, DOI: 10.1038/s41380-020-0653-4.Peer-Reviewed Original ResearchConceptsSynaptic gene expressionCircular RNAsGene expressionAlternative mRNA transcriptsDisease-associated circRNAsHomolog 1Neuronal RNAMRNA transcriptsRNASynaptic expressionAge of onsetMammalian brainCircRNAsPotential involvementDorsolateral prefrontal cortexOrbitofrontal cortexBipolar disorderPrefrontal cortexKnockdownExpressionFrontal cortexSynaptic plasticityNeuronal culturesPsychiatric diseasesMouse orbitofrontal cortex
2016
Can prenatal infection contribute to psychiatric disease in offspring?
Brennand K. Can prenatal infection contribute to psychiatric disease in offspring? Science Translational Medicine 2016, 8 DOI: 10.1126/scitranslmed.aaf3846.Commentaries, Editorials and Letters
2015
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Kocerha J, Dwivedi Y, Brennand K. Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease. Molecular Psychiatry 2015, 20: 677-684. PMID: 25824307, PMCID: PMC4440836, DOI: 10.1038/mp.2015.30.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPsychiatric diseasesPost-genome sequencing eraNew epigenetic targetsPotent epigenetic regulatorHuman Genome ProjectAttractive therapeutic potentialMicroRNA (miRNA) classNcRNA classesMajor neuronal pathwaysEpigenetic regulatorsSequencing eraEpigenetic targetsNoncoding RNAsGenome ProjectNeuronal pathwaysMultifactorial originPsychiatric disordersSingle proteinTherapeutic potentialReported rolesTherapeutic investigationsPleiotropic capacitySingle neuronsNeurobehavioral phenotypesDisease