2024
F91. MAPPING THE EFFECTS OF OPIOID USE DISORDER GENETIC ASSOCIATED VARIANTS IN BRAIN PATHWAYS AT A SINGLE CELL LEVEL
Rivera-Hernández M, Martínez-Magaña J, Brennand K, Montalvo-Ortiz J. F91. MAPPING THE EFFECTS OF OPIOID USE DISORDER GENETIC ASSOCIATED VARIANTS IN BRAIN PATHWAYS AT A SINGLE CELL LEVEL. European Neuropsychopharmacology 2024, 87: 254. DOI: 10.1016/j.euroneuro.2024.08.502.Peer-Reviewed Original ResearchOpioid use disorderDopaminergic neuronsReward-related learningOrbital frontal cortexGenetic variantsFunction of dopaminergic neuronsMap genetic variantsGenome-wide studiesCell projection organizationSingle-cell expression profilesCell typesOxytocin signaling pathwayPrefrontal cortexMotivated behaviorFrontal cortexDopaminergic pathwaysUse disorderBrain regionsModulation of chemical synaptic transmissionStriatumSingle-cell RNAseqCell-specific pathwaysBehavioral responsesScRNA-seqStriatum cells
2023
29. GENE EXPRESSION ASSOCIATIONS WITH TRAUMA IN HUMAN POSTMORTEM BRAIN
Hicks E, Seah C, Cote A, Ciarcia J, Chakka A, Group T, Brennand K, Nestler E, Girgenti M, Huckins L. 29. GENE EXPRESSION ASSOCIATIONS WITH TRAUMA IN HUMAN POSTMORTEM BRAIN. European Neuropsychopharmacology 2023, 75: s72. DOI: 10.1016/j.euroneuro.2023.08.139.Peer-Reviewed Original ResearchMajor depressive disorderPost-traumatic stress disorderHuman postmortem brainPostmortem brainsPsychiatric disordersNeurobiological consequencesTranscriptional signatureMajor precipitating factorEarly life stressCase/control statusGene expression associationsType of traumaStress-related disordersTrauma measuresTrauma-exposed individualsTraumatic Stress DisorderExpression associationsBrain donorsDepressive disorderMale miceFrontal cortexPrecipitating factorsMouse modelAnimal modelsPsychosocial stress
2020
A psychiatric disease-related circular RNA controls synaptic gene expression and cognition
Zimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell’Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, Perrone-Bizzozero N, Brigman JL, Mellios N. A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Molecular Psychiatry 2020, 25: 2712-2727. PMID: 31988434, PMCID: PMC7577899, DOI: 10.1038/s41380-020-0653-4.Peer-Reviewed Original ResearchConceptsSynaptic gene expressionCircular RNAsGene expressionAlternative mRNA transcriptsDisease-associated circRNAsHomolog 1Neuronal RNAMRNA transcriptsRNASynaptic expressionAge of onsetMammalian brainCircRNAsPotential involvementDorsolateral prefrontal cortexOrbitofrontal cortexBipolar disorderPrefrontal cortexKnockdownExpressionFrontal cortexSynaptic plasticityNeuronal culturesPsychiatric diseasesMouse orbitofrontal cortex