2021
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Powell SK, O’Shea C, Townsley K, Prytkova I, Dobrindt K, Elahi R, Iskhakova M, Lambert T, Valada A, Liao W, Ho SM, Slesinger PA, Huckins LM, Akbarian S, Brennand KJ. Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk. Molecular Psychiatry 2021, 28: 1970-1982. PMID: 34493831, PMCID: PMC8898985, DOI: 10.1038/s41380-021-01273-0.Peer-Reviewed Original ResearchConceptsInduced dopaminergic neuronsDopaminergic neuronsMidbrain dopaminergic neuron developmentNeuron identityHuman induced pluripotent stem cellsCannabis use disorderDopaminergic neuron developmentAction potential durationGlutamatergic neuronsDopamine synthesisSpontaneous burstsPotential durationUse disordersNeuronal subtypesPsychiatric diseasesBipolar disorderElectrophysiological propertiesDisease riskHyperpolarization potentialPsychiatric disease riskNeuron developmentOscillatory activityNeuronsHeterogenous cell populationsCell populations
2017
The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening
Gonzalez D, Gregory J, Brennand K. The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. Frontiers In Cell And Developmental Biology 2017, 5: 117. PMID: 29312938, PMCID: PMC5742170, DOI: 10.3389/fcell.2017.00117.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2008
Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics
Szotek P, Chang H, Brennand K, Fujino A, Pieretti-Vanmarcke R, Celso C, Dombkowski D, Preffer F, Cohen K, Teixeira J, Donahoe P. Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 12469-12473. PMID: 18711140, PMCID: PMC2527935, DOI: 10.1073/pnas.0805012105.Peer-Reviewed Original ResearchConceptsLabel-retaining cell populationStem/progenitor cellsSomatic stem/progenitor cellsEpithelial label-retaining cellsCoelomic epitheliumProgenitor cellsCell populationsCell-mediated processStem/progenitor cell characteristicsLabel-retaining cellsEstrous cyclingAdult miceProgenitor cell characteristicsMouse ovariesCytoprotective mechanismsSide population
2007
All β Cells Contribute Equally to Islet Growth and Maintenance
Brennand K, Huangfu D, Melton D. All β Cells Contribute Equally to Islet Growth and Maintenance. PLOS Biology 2007, 5: e163. PMID: 17535113, PMCID: PMC1877817, DOI: 10.1371/journal.pbio.0050163.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCell DifferentiationCell ProliferationFemaleGenes, ReporterGenetic MarkersGreen Fluorescent ProteinsHistonesIn Vitro TechniquesInsulin-Secreting CellsIslets of LangerhansMaleMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalMosaicismRecombinant Fusion ProteinsTetracyclineConceptsBeta-cell populationBeta cellsBeta-cell replicationHealthy adult miceBeta-cell poolCell populationsDifferentiated beta cellsStem cellsReplacement therapyCell replacement therapyAdult miceIslet growthΒ-cellsProtein expressionCell poolReplicative capacityCell replicationHepatocyte populationAdult stem cellsClonal analysisCellsLevel of fluorescenceFluorescent protein expressionPopulationDiabetes