2023
Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders
Ma Y, Bendl J, Hartley B, Fullard J, Abdelaal R, Ho S, Kosoy R, Gochman P, Rapoport J, Hoffman G, Brennand K, Roussos P. Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders. Biological Psychiatry 2023, 95: 187-198. PMID: 37454787, PMCID: PMC10787819, DOI: 10.1016/j.biopsych.2023.07.003.Peer-Reviewed Original ResearchConceptsTranscriptional programsBrain-related disordersGlutamatergic neuronsGene coexpression network analysisSignificant heritability enrichmentsEnhancer-promoter interactionsCoexpression network analysisDisease-associated genesExpression of genesLarge-scale geneticMultiomics data integrationChromatin accessibilityEpigenomic changesHeritability enrichmentGenetic regulationRegulatory elementsMultiple genesSequence variationGene expressionAxon guidanceGenetic riskPotassium chloride-induced depolarizationActivity-dependent changesDepolarization-induced changesGenes
2016
Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons
Roussos P, Guennewig B, Kaczorowski D, Barry G, Brennand K. Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons. JAMA Psychiatry 2016, 73: 1180-1188. PMID: 27732689, PMCID: PMC5437975, DOI: 10.1001/jamapsychiatry.2016.2575.Peer-Reviewed Original ResearchConceptsGene coexpression analysisActivity-dependent changesGene expressionCandidate genesCoexpression analysisSchizophrenia candidate genesSpecific molecular functionsGenome-wide profilingPluripotent stem cell-derived neuronsGene expression differencesSchizophrenia-associated variantsStem cell-derived neuronsDifferential expression analysisNeuronal activity-dependent changesHuman-induced pluripotent stem cell-derived neuronsCell-derived neuronsHuman-induced pluripotent stem cellsPluripotent stem cell neuronsPluripotent stem cellsCommon molecular pathwaysSchizophrenia risk genesMolecular functionsGene networksEtiopathogenesis of schizophreniaExpression analysis