Conformational Response of Influenza A M2 Transmembrane Domain to Amantadine Drug Binding at Low pH (pH 5.5)
Georgieva E, Borbat P, Grushin K, Stoilova-McPhie S, Kulkarni N, Liang Z, Freed J. Conformational Response of Influenza A M2 Transmembrane Domain to Amantadine Drug Binding at Low pH (pH 5.5). Frontiers In Physiology 2016, 7: 317. PMID: 27524969, PMCID: PMC4965473, DOI: 10.3389/fphys.2016.00317.Peer-Reviewed Original ResearchTransmembrane domainDouble electron-electron resonanceSingle transmembrane helixM2 transmembrane domainCore transmembrane domainNoticeable conformational changesC-terminal sideJuxtamembrane residuesTransmembrane helicesOligomer equilibriumHelix bundleConformational rearrangementsGolgi apparatusConformational responseM2 proteinStable tetramerConformational changesExit poreProton channelChannel closureG34A mutationSpecific mutationsLipid bilayersLow pH environmentViral cycle