Mediator-dependent secondary injury after unilateral blunt thoracic trauma.
Melton S, Davis K, Moomey C, Fabian T, Proctor K. Mediator-dependent secondary injury after unilateral blunt thoracic trauma. Shock 1999, 11: 396-402. PMID: 10454828.Peer-Reviewed Original ResearchConceptsChest traumaNaive recipientsRespiratory failureTube thoracostomyCross-transfusion experimentsEarly pharmacologic interventionBlunt chest traumaPulmonary vascular resistanceSevere chest traumaBlunt thoracic traumaVascular resistanceSupportive careCardiopulmonary changesThoracic traumaExchange transfusionLung compliancePathophysiologic sequencePrimary injurySecondary injuryMediator productionCardiac outputPharmacologic interventionsHistologic changesInflammatory processStroke volumeProstanoids
Davis K, Fabian T, Croce M, Proctor K. Prostanoids. Journal Of Trauma And Acute Care Surgery 1999, 46: 824-832.. PMID: 10338399, DOI: 10.1097/00005373-199905000-00010.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressurePulmonary capillary leakEnd-expiratory pressurePMN infiltrationPulmonary failureRight thoraxSecondary injuryInflammatory responseCapillary leakPlatelet-derived thromboxaneBlunt chest traumaHours of injurySecondary inflammatory responseBronchoalveolar lavage proteinSerial bronchoalveolar lavagesCyclooxygenase inhibitor indomethacinUnilateral pulmonary contusionPulmonary contusionChest traumaProfound hypoxemiaSham injuryBlunt injuryLeft lungBronchoalveolar lavageNeutrophil content