2001
COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA. Shock 2001, 15: 479-484. PMID: 11386622, DOI: 10.1097/00024382-200115060-00012.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal AbscessAbdominal InjuriesAminoimidazole CarboxamideAnimalsAnti-Inflammatory AgentsBlood PressureCapillariesDisease Models, AnimalHemodynamicsInflammationLactatesLungLung InjuryNeutrophilsPulmonary AlveoliPulmonary ArteryResuscitationRibonucleotidesShock, HemorrhagicSteroidsSwineConceptsSecondary lung injuryAbdominal traumaG-CSFPMN activationLung injuryHemorrhagic shockAnalysis of BALLate septic complicationsLavage leukocyte countPulmonary reperfusion injurySecondary pulmonary changesAnti-inflammatory drugsAnti-inflammatory metabolitesWhite blood cellsNeutrophil sequestrationPulmonary contusionSeptic complicationsPMN infiltrationPulmonary changesReperfusion injurySecondary injuryResuscitation strategiesShed bloodCombination therapyEndogenous adenosine
1999
Mediator-dependent secondary injury after unilateral blunt thoracic trauma.
Melton S, Davis K, Moomey C, Fabian T, Proctor K. Mediator-dependent secondary injury after unilateral blunt thoracic trauma. Shock 1999, 11: 396-402. PMID: 10454828.Peer-Reviewed Original ResearchConceptsChest traumaNaive recipientsRespiratory failureTube thoracostomyCross-transfusion experimentsEarly pharmacologic interventionBlunt chest traumaPulmonary vascular resistanceSevere chest traumaBlunt thoracic traumaVascular resistanceSupportive careCardiopulmonary changesThoracic traumaExchange transfusionLung compliancePathophysiologic sequencePrimary injurySecondary injuryMediator productionCardiac outputPharmacologic interventionsHistologic changesInflammatory processStroke volume