2001
COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA. Shock 2001, 15: 479-484. PMID: 11386622, DOI: 10.1097/00024382-200115060-00012.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal AbscessAbdominal InjuriesAminoimidazole CarboxamideAnimalsAnti-Inflammatory AgentsBlood PressureCapillariesDisease Models, AnimalHemodynamicsInflammationLactatesLungLung InjuryNeutrophilsPulmonary AlveoliPulmonary ArteryResuscitationRibonucleotidesShock, HemorrhagicSteroidsSwineConceptsSecondary lung injuryAbdominal traumaG-CSFPMN activationLung injuryHemorrhagic shockAnalysis of BALLate septic complicationsLavage leukocyte countPulmonary reperfusion injurySecondary pulmonary changesAnti-inflammatory drugsAnti-inflammatory metabolitesWhite blood cellsNeutrophil sequestrationPulmonary contusionSeptic complicationsPMN infiltrationPulmonary changesReperfusion injurySecondary injuryResuscitation strategiesShed bloodCombination therapyEndogenous adenosine
1999
Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis. Surgery 1999, 126: 305-313. PMID: 10455899, DOI: 10.1016/s0039-6060(99)70170-4.Peer-Reviewed Original ResearchConceptsGranulocyte colony-stimulating factorG-CSFColony-stimulating factorPMN cytotoxicityReperfusion injurySeptic focusPeritoneal PMNsResuscitation fluidExogenous granulocyte colony-stimulating factorIntra-abdominal septic focusLung tissue myeloperoxidaseIntra-abdominal sepsisBronchoalveolar lavage proteinLocal host defenseSaline solution vehicleBroad-spectrum antibioticsBronchoalveolar lavage PMNsLavage PMNsPeritoneal neutrophiliaTissue myeloperoxidaseSeptic complicationsAbdominal traumaPMN infiltrationTrauma patientsCecal ligation