2004
Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model
Davis KA, Santaniello JM, He LK, Muthu K, Sen S, Jones SB, Gamelli RL, Shankar R. Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model. Journal Of Trauma And Acute Care Surgery 2004, 56: 272-278. PMID: 14960967, DOI: 10.1097/01.ta.0000108995.64133.90.Peer-Reviewed Original ResearchConceptsColony-stimulating factorPulmonary sepsisCytokine tumor necrosisSystemic sepsisInterleukin-6Tumor necrosisProinflammatory cytokine tumor necrosisInflammatory cytokine tumor necrosisAlveolar macrophage releaseBurn/traumaDorsal scald burnGram stainMultiple organ failureDevelopment of pneumoniaGranulocyte-macrophage (GM) CSFFemoral bone marrow cellsEnd-organ responseIsolated alveolar macrophagesPositive tissue culturesPseudomonas aeruginosaWhole lung tissueMale B6D2F1 miceTissue Gram stainMacrophage colony-stimulating factorBone marrow cells
1999
Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis. Surgery 1999, 126: 305-313. PMID: 10455899, DOI: 10.1016/s0039-6060(99)70170-4.Peer-Reviewed Original ResearchConceptsGranulocyte colony-stimulating factorG-CSFColony-stimulating factorPMN cytotoxicityReperfusion injurySeptic focusPeritoneal PMNsResuscitation fluidExogenous granulocyte colony-stimulating factorIntra-abdominal septic focusLung tissue myeloperoxidaseIntra-abdominal sepsisBronchoalveolar lavage proteinLocal host defenseSaline solution vehicleBroad-spectrum antibioticsBronchoalveolar lavage PMNsLavage PMNsPeritoneal neutrophiliaTissue myeloperoxidaseSeptic complicationsAbdominal traumaPMN infiltrationTrauma patientsCecal ligation