2010
Factors Associated With Survival Following Blunt Chest Trauma in Older Patients: Results From a Large Regional Trauma Cooperative
Harrington DT, Phillips B, Machan J, Zacharias N, Velmahos GC, Rosenblatt MS, Winston E, Patterson L, Desjardins S, Winchell R, Brotman S, Churyla A, Schulz JT, Maung AA, Davis KA. Factors Associated With Survival Following Blunt Chest Trauma in Older Patients: Results From a Large Regional Trauma Cooperative. JAMA Surgery 2010, 145: 432-437. PMID: 20479340, DOI: 10.1001/archsurg.2010.71.Peer-Reviewed Original ResearchConceptsHigh-volume trauma centerInjury Severity ScoreCongestive heart failurePatient-controlled analgesiaRib fracturesTrauma centerSeverity scoreOlder patientsHeart failureMultivariable analysisTraumatic rib fracturesBlunt chest traumaPatient dataDevelopment of pneumoniaCoronary artery diseaseLevel I centersTraumatic chest injuriesStandard care practicesChest scoreChest traumaArtery diseaseImproved survivalIndependent predictorsPatient factorsUnivariable analysis
2000
Endogenous Adenosine and Secondary Injury after Chest Trauma
Davis K, Fabian T, Ragsdale D, Trenthem L, Proctor A. Endogenous Adenosine and Secondary Injury after Chest Trauma. Journal Of Trauma And Acute Care Surgery 2000, 49: 892-898. PMID: 11086782, DOI: 10.1097/00005373-200011000-00017.Peer-Reviewed Original ResearchConceptsBlunt chest traumaBlunt chest injuryChest traumaAdenosine-regulating agentSecondary injuryBAL proteinChest injuriesEndogenous adenosineLung myeloperoxidase levelsTime of resuscitationAnti-inflammatory actionProgressive inflammatory responseAction of adenosineAlveolar-capillary membraneWet-dry ratioBAL WBCPulmonary contusionContralateral lungMyeloperoxidase levelsSystemic hemodynamicsUninjured lungsLung edemaRight chestMongrel pigsPathophysiologic changes
1999
Mediator-dependent secondary injury after unilateral blunt thoracic trauma.
Melton S, Davis K, Moomey C, Fabian T, Proctor K. Mediator-dependent secondary injury after unilateral blunt thoracic trauma. Shock 1999, 11: 396-402. PMID: 10454828.Peer-Reviewed Original ResearchConceptsChest traumaNaive recipientsRespiratory failureTube thoracostomyCross-transfusion experimentsEarly pharmacologic interventionBlunt chest traumaPulmonary vascular resistanceSevere chest traumaBlunt thoracic traumaVascular resistanceSupportive careCardiopulmonary changesThoracic traumaExchange transfusionLung compliancePathophysiologic sequencePrimary injurySecondary injuryMediator productionCardiac outputPharmacologic interventionsHistologic changesInflammatory processStroke volumeProstanoids
Davis K, Fabian T, Croce M, Proctor K. Prostanoids. Journal Of Trauma And Acute Care Surgery 1999, 46: 824-832.. PMID: 10338399, DOI: 10.1097/00005373-199905000-00010.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressurePulmonary capillary leakEnd-expiratory pressurePMN infiltrationPulmonary failureRight thoraxSecondary injuryInflammatory responseCapillary leakPlatelet-derived thromboxaneBlunt chest traumaHours of injurySecondary inflammatory responseBronchoalveolar lavage proteinSerial bronchoalveolar lavagesCyclooxygenase inhibitor indomethacinUnilateral pulmonary contusionPulmonary contusionChest traumaProfound hypoxemiaSham injuryBlunt injuryLeft lungBronchoalveolar lavageNeutrophil content