Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. Granulocyte colony-stimulating factor and neutrophil-related changes in local host defense during recovery from shock and intra-abdominal sepsis. Surgery 1999, 126: 305-313. PMID: 10455899, DOI: 10.1016/s0039-6060(99)70170-4.Peer-Reviewed Original ResearchConceptsGranulocyte colony-stimulating factorG-CSFColony-stimulating factorPMN cytotoxicityReperfusion injurySeptic focusPeritoneal PMNsResuscitation fluidExogenous granulocyte colony-stimulating factorIntra-abdominal septic focusLung tissue myeloperoxidaseIntra-abdominal sepsisBronchoalveolar lavage proteinLocal host defenseSaline solution vehicleBroad-spectrum antibioticsBronchoalveolar lavage PMNsLavage PMNsPeritoneal neutrophiliaTissue myeloperoxidaseSeptic complicationsAbdominal traumaPMN infiltrationTrauma patientsCecal ligation