2024
Nanotechnology approaches to drug delivery for the treatment of ischemic stroke
Peng B, Mohammed F, Tang X, Liu J, Sheth K, Zhou J. Nanotechnology approaches to drug delivery for the treatment of ischemic stroke. Bioactive Materials 2024, 43: 145-161. PMID: 39386225, PMCID: PMC11462157, DOI: 10.1016/j.bioactmat.2024.09.016.Peer-Reviewed Original ResearchBlood-brain barrierClinical translationClinical trialsFDA-approved pharmacotherapiesReview therapeutic agentsIschemic strokeTherapeutic agentsEffective treatment optionDrug deliveryTreatment of ischemic strokePotential clinical translationGlobal public health concernImprove delivery efficiencyTreatment optionsTreatment strategiesIschemic brainPublic health concernStroke pharmacotherapyEngineered nanoparticlesStroke treatment strategiesDelivery efficiencyNanotechnological approachesDrugPharmacotherapyStrokeCorrelations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence
Stulberg E, Lisabeth L, Schneider A, Skolarus L, Kershaw K, Zheutlin A, Harris B, Sarpong D, Wong K, Sheth K, de Havenon A. Correlations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence. Annals Of Neurology 2024, 96: 739-744. PMID: 39056317, DOI: 10.1002/ana.27039.Peer-Reviewed Original ResearchSocioeconomic statusStroke prevalenceCounty-level socioeconomic statusSocioeconomic status measuresHealth care accessCenters for Disease Control and PreventionRisk factor measurementsDisease Control and PreventionPrevalence of adultsFederal poverty levelControl and PreventionCare accessStroke metricsStroke riskPoverty levelObservational researchPrevalenceClinical determinantsCommunity estimatesEcological studiesStrokeFactor measurementsHealthInterventionAdultsDiffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients
Sorby‐Adams A, Guo J, de Havenon A, Payabvash S, Sze G, Pinter N, Jaikumar V, Siddiqui A, Baldassano S, Garcia‐Guarniz A, Zabinska J, Lalwani D, Peasley E, Goldstein J, Nelson O, Schaefer P, Wira C, Pitts J, Lee V, Muir K, Nimjee S, Kirsch J, Iglesias J, Rosen M, Sheth K, Kimberly W. Diffusion‐Weighted Imaging Fluid‐Attenuated Inversion Recovery Mismatch on Portable, Low‐Field Magnetic Resonance Imaging Among Acute Stroke Patients. Annals Of Neurology 2024, 96: 321-331. PMID: 38738750, PMCID: PMC11293843, DOI: 10.1002/ana.26954.Peer-Reviewed Original ResearchStroke patientsAcute ischemic strokeCut-pointsIschemic strokeStroke patients <Diagnosis of acute ischemic strokeSignal intensity ratioFluid-attenuated inversion recoveryAcute stroke patientsOptimal cut-pointMagnetic resonance imagingDiffusion-weighted imagingDWI-FLAIR mismatchStroke onsetTrained assessorsNational InstituteStrokeThrombolytic interventionNegative predictive valueFLAIR hyperintensitiesPatientsInterobserver agreementHyperacute strokeDiffusion-weightedPredictive valueTwenty Years of Get With The Guidelines-Stroke: Celebrating Past Successes, Lessons Learned, and Future Challenges
Reeves M, Fonarow G, Smith E, Sheth K, Messe S, Schwamm L. Twenty Years of Get With The Guidelines-Stroke: Celebrating Past Successes, Lessons Learned, and Future Challenges. Stroke 2024, 55: 1689-1698. PMID: 38738376, PMCID: PMC11208062, DOI: 10.1161/strokeaha.124.046527.Peer-Reviewed Original Research
2023
The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort
Singh S, Oreskovic T, Carr S, Papier K, Conroy M, Senff J, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Marini S, Nunley C, Newhouse A, Ouyang A, Brouwers H, Westover B, Rivier C, Falcone G, Howard V, Howard G, Pikula A, Ibrahim S, Sheth K, Yechoor N, Lazar R, Anderson C, Tanzi R, Fricchione G, Littlejohns T, Rosand J. The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort. Frontiers In Neurology 2023, 14: 1291020. PMID: 38107629, PMCID: PMC10725202, DOI: 10.3389/fneur.2023.1291020.Peer-Reviewed Original ResearchRisk of dementiaIncident casesIncident dementiaCare scoresLower riskCox proportional hazards regressionSubsequent incident dementiaProportional hazards regressionUK Biobank cohortHazards regressionBaseline evaluationSignificant associationAge groupsDementiaBiobank cohortStrokeDelphi processLifestyle choicesPatientsUKB participantsRiskBaselineBehavior changeAssociationPredictive validityPriorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke
Samaniego E, Boltze J, Lyden P, Hill M, Campbell B, Silva G, Sheth K, Fisher M, Hillis A, Nguyen T, Carone D, Favilla C, Deljkich E, Albers G, Heit J, Lansberg M, Aksoy D, Broderick J, Castonguay A, Ghosh S, Grotta J, Harston G, Houser G, Kuchenbecker K, Latour L, Liebeskind D, Kylan Lynch J, Maier C, Mistry E, Mocco J, Nogueira R, Saver J, van Vlimmeren M, Wakhloo A, Wechsler L. Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke. Stroke 2023, 54: 3190-3201. PMID: 37942645, PMCID: PMC10841844, DOI: 10.1161/strokeaha.123.044985.Peer-Reviewed Original ResearchConceptsAcute strokeDiagnostic workupAcute ischemic stroke treatmentAcute ischemic strokeComprehensive stroke centerHigh-resolution vessel wallCerebral Infarction (TICI) scaleIschemic stroke treatmentMobile stroke unitIschemic strokeStroke centersStroke treatmentStroke unitReperfusion outcomesPatient outcomesEarly ischemiaCone beamStrokeVessel wallWorkupAcademic investigatorsOutcomesTomographyThrombolysisReperfusionImprovement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity
de Havenon A, Smith E, Sharma R, Falcone G, Bangad A, Prabhakaran S, Sheth K. Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity. Journal Of The American Heart Association 2023, 12: e029374. PMID: 37345754, PMCID: PMC10356061, DOI: 10.1161/jaha.123.029374.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesIncident strokePrimary outcomeHypertensive individualsMatter hyperintensitiesAtherosclerotic cardiovascular disease risk scoreCognitive impairmentCardiovascular disease risk scoreVascular risk factorsCurrent cigarette smokingDisease risk scoreMagnetic resonance imagingLogistic regression modelsRandomization armCerebrovascular eventsVascular riskCigarette smokingPrognostic informationRisk factorsPrognostic abilityRisk scoreCognitive declineResonance imagingDeLong testStrokeNeighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001)
Torres-Lopez V, Renedo D, Acosta J, Gill T, Sheth K, Falcone G, Rivier C. Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202154.Peer-Reviewed Original ResearchGenetic Analyses of Oral Health and Neuroimaging Markers of Brain Health in Persons without Stroke (S49.001)
Rivier C, Renedo D, De Havenon A, Payabvash S, Torres-Lopez V, Gill T, Sheth K, Falcone G. Genetic Analyses of Oral Health and Neuroimaging Markers of Brain Health in Persons without Stroke (S49.001). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202220.Peer-Reviewed Original ResearchSleep Duration is Associated with Clinically Silent Brain Injury in Middle-Aged Persons without Stroke (P1-13.004)
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Torres-Lopez V, Payabvash S, Sheth K, Gill T, Falcone G. Sleep Duration is Associated with Clinically Silent Brain Injury in Middle-Aged Persons without Stroke (P1-13.004). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202523.Peer-Reviewed Original ResearchNeighborhood Deprivation and Polygenic Contribution to Acute Ischemic Stroke: Results from the All of Us Research Program (S49.007)
Rivier C, Acosta J, Renedo D, Gill T, Sheth K, Falcone G. Neighborhood Deprivation and Polygenic Contribution to Acute Ischemic Stroke: Results from the All of Us Research Program (S49.007). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202793.Peer-Reviewed Original ResearchInvestigating the Relationship Between Oximetry Trends During Endovascular Therapy and Neurological Worsening for Patients with Acute Ischemic Stroke (S24.006)
Olexa M, Begunova Y, Bartolome D, Peng T, Matouk C, Sheth K, Petersen N. Investigating the Relationship Between Oximetry Trends During Endovascular Therapy and Neurological Worsening for Patients with Acute Ischemic Stroke (S24.006). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202997.Peer-Reviewed Original ResearchHemorrhagic Conversion of Acute Ischemic Stroke
Zubair A, Sheth K. Hemorrhagic Conversion of Acute Ischemic Stroke. Neurotherapeutics 2023, 20: 705-711. PMID: 37085684, PMCID: PMC10275827, DOI: 10.1007/s13311-023-01377-1.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHemorrhagic conversionIschemic strokeTreatment of patientsHemorrhagic transformationEndovascular thrombectomySerious complicationsThrombolytic therapyTreatment optionsRisk factorsLeading causePatient outcomesCurrent treatmentTimely managementStrokePatientsTreatmentThrombectomyMorbidityComplicationsReviewPathophysiologyTherapyMortalityDiagnosis
2022
Technical Dissonance in Home Blood Pressure Monitoring After Stroke: Having the Machine, but Not Using Correctly.
Forman R, Viscoli C, Meurer K, Sheth K, Sansing L, de Havenon A, Sharma R, Mariscal M, Kernan W. Technical Dissonance in Home Blood Pressure Monitoring After Stroke: Having the Machine, but Not Using Correctly. American Journal Of Hypertension 2022, 36: 195-200. PMID: 36520024, PMCID: PMC10016067, DOI: 10.1093/ajh/hpac129.Peer-Reviewed Original ResearchConceptsHome blood pressure monitoringBlood pressure monitoringBlood pressurePressure monitoringNon-Hispanic white patientsProportion of patientsCross-sectional studyNon-Hispanic white participantsStroke recurrenceRate of useMost patientsPrimary outcomeWhite patientsRate of possessionPatientsUnderrepresented patientsArm cuffHypertensionStrokeCorrect useWhite participantsSignificant disparitiesEthnic groupsParticipantsQuality of techniqueCholesterol-Lowering Medication Use Prior to Ischemic Strokes Secondary to Large Artery Atherosclerosis or Small Vessel Disease: A Single Center Study (S35.009)
Garg A, Baker A, Faridi K, De Havenon A, Sheth K, Forman R, Sharma R. Cholesterol-Lowering Medication Use Prior to Ischemic Strokes Secondary to Large Artery Atherosclerosis or Small Vessel Disease: A Single Center Study (S35.009). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3531.Peer-Reviewed Original ResearchWORSE VASCULAR RISK FACTOR CONTROL IN PATIENTS WITH STROKE COMPARED TO PATIENTS WITH MYOCARDIAL INFARCTION
Leasure A, Acosta J, Schwartz A, Forman R, Sharma R, de Havenon A, Falcone G, Inzucchi S, Kernan W, Sheth K. WORSE VASCULAR RISK FACTOR CONTROL IN PATIENTS WITH STROKE COMPARED TO PATIENTS WITH MYOCARDIAL INFARCTION. Journal Of The American College Of Cardiology 2022, 79: 1504. DOI: 10.1016/s0735-1097(22)02495-0.Peer-Reviewed Original Research
2021
Primary stroke prevention worldwide: translating evidence into action
Owolabi M, Thrift A, Mahal A, Ishida M, Martins S, Johnson W, Pandian J, Abd-Allah F, Yaria J, Phan H, Roth G, Gall S, Beare R, Phan T, Mikulik R, Akinyemi R, Norrving B, Brainin M, Feigin V, Group S, Abanto C, Abera S, Addissie A, Adebayo O, Adeleye A, Adilbekov Y, Adilbekova B, Adoukonou T, de Sousa D, Ajagbe T, Akhmetzhanova Z, Akpalu A, Ahlgren J, Ameriso S, Andonova S, Awoniyi F, Bakhiet M, Barboza M, Basri H, Bath P, Bello O, Bereczki D, Beretta S, Berkowitz A, Bernabé-Ortiz A, Bernhardt J, Berzina G, Bisharyan M, Bovet P, Budincevic H, Cadilhac D, Caso V, Chen C, Chin J, Chwojnicki K, Conforto A, Cruz V, D'Amelio M, Danielyan K, Davis S, Demarin V, Dempsey R, Dichgans M, Dokova K, Donnan G, Elkind M, Endres M, Fischer U, Gankpé F, Saavedra A, Gil A, Giroud M, Gnedovskaya E, Hachinski V, Hafdi M, Hamadeh R, Hamzat T, Hankey G, Heldner M, Ibrahim E, Ibrahim N, Inoue M, Jee S, Jeng J, Kalkonde Y, Kamenova S, Karaszewski B, Kelly P, Khan T, Kiechl S, Kondybayeva A, Kõrv J, Kravchenko M, Krishnamurthi R, Kruja J, Lakkhanaloet M, Langhorne P, Lavados P, Law Z, Lawal A, Lazo-Porras M, Lebedynets D, Lee T, Leung T, Liebeskind D, Lindsay P, López-Jaramillo P, Lotufo P, Machline-Carrion J, Makanjuola A, Markus H, Marquez-Romero J, Medina M, Medukhanova S, Mehndiratta M, Merkin A, Mirrakhimov E, Mohl S, Moscoso-Porras M, Müller-Stierlin A, Murphy S, Musa K, Nasreldein A, Nogueira R, Nolte C, Noubiap J, Novarro-Escudero N, Ogun Y, Oguntoye R, Oraby M, Osundina M, Ovbiagele B, Orken D, Ozdemir A, Ozturk S, Paccot M, Phromjai J, Piradov P, Platz T, Potpara T, Ranta A, Rathore F, Richard E, Sacco R, Sahathevan R, Carquín I, Saposnik G, Sarfo F, Sharma M, Sheth K, Shobhana A, Suwanwela N, Svyato I, Sylaja P, Tao X, Thakur K, Toni D, Topcuoglu M, Torales J, Towfighi A, Truelsen T, Tsiskaridze A, Tulloch-Reid M, Useche N, Vanacker P, Vassilopoulou S, Vukorepa G, Vuletic V, Wahab K, Wang W, Wijeratne T, Wolfe C, Yifru Y, Yock-Corrales A, Yonemoto N, Yperzeele L, Zhang P. Primary stroke prevention worldwide: translating evidence into action. The Lancet Public Health 2021, 7: e74-e85. PMID: 34756176, PMCID: PMC8727355, DOI: 10.1016/s2468-2667(21)00230-9.Peer-Reviewed Original ResearchConceptsPrimary stroke preventionStroke preventionCause of disabilityPopulation-wide strategiesPrimary prevention servicesCause of deathCosts of strokeMiddle-income countriesPrimary preventionHealth Policy paperPrevention servicesHealth professionalsHealth systemPreventionStrokeEntire populationCausePatientsLife courseRace/Ethnicity Considerations in the Prevention and Treatment of Stroke
Forman R, Sheth K. Race/Ethnicity Considerations in the Prevention and Treatment of Stroke. Current Treatment Options In Neurology 2021, 23: 33. DOI: 10.1007/s11940-021-00684-2.Peer-Reviewed Original ResearchStroke risk factorsGreater Cincinnati/Northern Kentucky Stroke StudyRisk factorsBlack individualsRate of strokeHospital arrival timeWhite individualsTreatment of strokeRecent FindingsMultiple studiesPurpose of ReviewToHigh mortality rateStroke outcomeHemorrhagic strokeStroke treatmentWhite patientsBlack patientsStroke disparitiesStroke patientsStroke StudyTimely treatmentMortality rateGreater incidenceGreater severityEthnic disparitiesStrokeExtracranial Hemorrhage in the Setting of Gastrointestinal or Genitourinary Cancer is Associated with Increased Risk of Ischemic Stroke in Patients with Atrial Fibrillation (1373)
Zhou E, Lord A, Boehme A, Henninger N, De Havenon A, Vahidy F, Ishida K, Torres J, Mistry E, Mac Grory B, Sheth K, Gurol E, Furie K, Elkind M, Yaghi S. Extracranial Hemorrhage in the Setting of Gastrointestinal or Genitourinary Cancer is Associated with Increased Risk of Ischemic Stroke in Patients with Atrial Fibrillation (1373). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1373.Peer-Reviewed Original ResearchPrehospital Blood Pressure Reductions Are Associated with Neurologic Worsening in Patients With Large-vessel Occlusion Stroke (2844)
Kobsa J, Prasad A, Soto A, Kodali S, Nguyen C, Peshwe K, Orozco D, Farooqui M, Zevallos C, Sansing L, Schindler J, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Prehospital Blood Pressure Reductions Are Associated with Neurologic Worsening in Patients With Large-vessel Occlusion Stroke (2844). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2844.Peer-Reviewed Original Research