2022
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results
Lyden PD, Bosetti F, Diniz MA, Rogatko A, Koenig JI, Lamb J, Nagarkatti KA, Cabeen RP, Hess DC, Kamat PK, Khan MB, Wood K, Dhandapani K, Arbab AS, Leira EC, Chauhan AK, Dhanesha N, Patel RB, Kumskova M, Thedens D, Morais A, Imai T, Qin T, Ayata C, Boisserand LSB, Herman AL, Beatty HE, Velazquez SE, Diaz-Perez S, Sanganahalli BG, Mihailovic JM, Hyder F, Sansing LH, Koehler RC, Lannon S, Shi Y, Karuppagounder SS, Bibic A, Akhter K, Aronowski J, McCullough LD, Chauhan A, Goh A, Siddiqui S, Sheth K, Matouk C, Cruz C, Zhou J, Dawson V, Dawson T, Liang J, van Zijl P, Zeiler S, Taylor Kimberly W, Erdogan T, Yu L, Mandeville J, Whittier J. The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results. Stroke 2022, 53: 1802-1812. PMID: 35354299, PMCID: PMC9038686, DOI: 10.1161/strokeaha.121.038047.Peer-Reviewed Original ResearchConceptsPreclinical assessmentStroke treatmentCandidate treatmentMiddle cerebral artery occlusion (MCAO) surgeryClinical stroke trialsSuccessful stroke treatmentInclusion/exclusion criteriaStroke clinical trialsClinical trial designYoung male animalsComorbid diseasesOcclusion surgeryCerebral ischemiaNeurological disabilityComorbid conditionsStroke trialsProtocol adherenceBlinded assessmentSuch therapyClinical trialsClinical studiesExclusion criteriaTrial designAged animalsOutcome assessment
2017
Chapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice
Urday S, Sheth K, Simard J. Chapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice. 2017, 183-198. DOI: 10.1016/b978-0-12-803196-4.00010-2.Peer-Reviewed Original ResearchSUR1-TRPM4Brain edemaEdema formationDefinitive phase III studyBrain edema treatmentNeurocritical care conditionsPhase III studyAcute neurological injuryExtravasation of bloodType of edemaMicrovascular failureIII studySignificant morbidityNeurological functionNeurological injuryEdema treatmentSafe medicationSelective blockadeLesion volumeClinical studiesPetechial hemorrhagesCare conditionsEdemaClinical practiceSulfonylurea receptor