2013
Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair
Guttmann DM, Hart L, Du K, Seletsky A, Koumenis C. Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair. International Journal Of Radiation Oncology • Biology • Physics 2013, 87: 168-175. PMID: 23849696, DOI: 10.1016/j.ijrobp.2013.05.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell Line, TumorDNA RepairDNA-Binding ProteinsDNA, NeoplasmGene Knockdown TechniquesHead and Neck NeoplasmsHistonesHSP27 Heat-Shock ProteinsHumansMiceMice, NudeOligonucleotidesProtein Serine-Threonine KinasesRadiation ToleranceRNA, Small InterferingTumor Suppressor ProteinsConceptsShort hairpin RNANeck cancer cell linesCancer cell linesNeck cancerNude miceTumor growthHsp27 knockdownRadiotherapy of headFractionated radiation therapyFaDu human headEffect of Hsp27Cell linesEffective clinical agentRole of HSP27LNA treatmentFlank tumorsRadiation therapyTumor xenograftsDeoxyribonucleic acid repairTumor radiosensitizationClonogenic survivalClinical agentsHairpin RNAHSP27DNA repair signaling
2003
Myocardin Is a Critical Serum Response Factor Cofactor in the Transcriptional Program Regulating Smooth Muscle Cell Differentiation
Du KL, Ip HS, Li J, Chen M, Dandre F, Yu W, Lu MM, Owens GK, Parmacek MS. Myocardin Is a Critical Serum Response Factor Cofactor in the Transcriptional Program Regulating Smooth Muscle Cell Differentiation. Molecular And Cellular Biology 2003, 23: 2425-2437. PMID: 12640126, PMCID: PMC150745, DOI: 10.1128/mcb.23.7.2425-2437.2003.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DifferentiationCells, CulturedCOS CellsDNA, ComplementaryGene Expression Regulation, DevelopmentalHumansMiceMicrofilament ProteinsMolecular Sequence DataMuscle ProteinsMuscle, SmoothMuscle, Smooth, VascularMyocardiumNuclear ProteinsOrgan SpecificityPromoter Regions, GeneticRatsRNA, Small InterferingSequence AlignmentSerum Response FactorStem CellsTrans-ActivatorsTranscriptional ActivationConceptsSerum response factorExpression of myocardinTranscriptional programsSerum Response Factor CofactorMyocardin geneSRF DNA-binding domainSmooth muscle cell lineageFunction of myocardinSmooth muscle cell differentiationDNA-binding domainMuscle cell lineageMuscle cell differentiationTranscription factor myocardinTranscriptional regulatory elementsUndifferentiated mouse ES cellsEmbryonic stem cellsMouse ES cellsAlpha promoter activitySmooth muscle alpha-actinSM22 alphaMuscle alpha-actinMutant proteinsVisceral SMCsEmbryonic developmentRegulatory elements