2020
Effect of Time to Surgery of Colorectal Liver Metastases on Survival
Chen EY, Mayo SC, Sutton T, Kearney MR, Kardosh A, Vaccaro GM, Billingsley KG, Lopez CD. Effect of Time to Surgery of Colorectal Liver Metastases on Survival. Journal Of Gastrointestinal Cancer 2020, 52: 169-176. PMID: 32086781, PMCID: PMC7900034, DOI: 10.1007/s12029-020-00372-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantColorectal NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHepatectomyHumansKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesTime FactorsTime-to-TreatmentYoung AdultConceptsColorectal liver metastasesLong-term OSPostoperative overall survivalOverall survivalLonger TTSLiver metastasesWorse survivalDiagnosis of CLMLong-term survivorsResultsTwo hundred eightyRisk of recurrenceComprehensive cancer centerHigh disease burdenSpecific primary tumorsShorter TTSPerioperative chemotherapyPostoperative chemotherapyPerioperative treatmentResection marginsCancer CenterMetastasis characteristicsInstitutional databasePrimary tumorDisease burdenSimilar survival
2018
Epirubicin and Ifosfamide with Preoperative Radiation for High-Risk Soft Tissue Sarcomas
Lu E, Perlewitz KS, Hayden JB, Hung AY, Doung YC, Davis LE, Mansoor A, Vetto JT, Billingsley KG, Kaempf A, Park B, Ryan CW. Epirubicin and Ifosfamide with Preoperative Radiation for High-Risk Soft Tissue Sarcomas. Annals Of Surgical Oncology 2018, 25: 920-927. PMID: 29388122, DOI: 10.1245/s10434-018-6346-4.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasHigh-risk soft tissue sarcomasPhase II studyII studyPreoperative radiationTissue sarcomasHigh-grade soft tissue sarcomasHigh-risk STS patientsDistant disease-free survivalM2/dayExtensive institutional experienceLocal-regional failureDisease-free survivalRetrospective chart reviewDose-intense chemotherapyFavorable clinical outcomePercent of tumorsGy of radiationPostoperative cyclesTrimodality therapyPreoperative therapyWound complicationsChart reviewOverall survivalPathologic response
2014
Chemoradiotherapy with a Radiation Boost for Anal Cancer Decreases the Risk for Salvage Abdominoperineal Resection: Analysis From the National Cancer Data Base
Geltzeiler C, Nabavizadeh N, Kim J, Lu K, Billingsley K, Thomas C, Herzig D, Tsikitis V. Chemoradiotherapy with a Radiation Boost for Anal Cancer Decreases the Risk for Salvage Abdominoperineal Resection: Analysis From the National Cancer Data Base. Annals Of Surgical Oncology 2014, 21: 3616-3620. PMID: 24943237, DOI: 10.1245/s10434-014-3849-5.Peer-Reviewed Original Research
2013
Coagulopathy after a liver resection: is it over diagnosed and over treated?
Barton J, Riha G, Differding J, Underwood S, Curren J, Sheppard B, Pommier R, Orloff S, Schreiber M, Billingsley K. Coagulopathy after a liver resection: is it over diagnosed and over treated? Hepato Pancreato Biliary 2013, 15: 865-871. PMID: 23458574, PMCID: PMC4503284, DOI: 10.1111/hpb.12051.Peer-Reviewed Original ResearchConceptsProthrombin time-international normalized ratioPost-operative time pointsLiver resectionPost-operative day 1Initiation of thromboprophylaxisLiver resection patientsNormal coagulation functionTime pointsPT-INR valuesTime of onsetProphylactic anticoagulationElective hepatectomyResection patientsPlasma transfusionHypercoagulable stateAnesthetic techniqueCoagulation functionNormalized ratioPlasma therapyPringle manoeuverRelative hypercoagulabilityFunctional assessmentDay 1ResectionThrombelastography
2011
Predicting malignant intraductal papillary mucinous neoplasm: a single-center review
Cone M, Rea J, Diggs B, Douthit M, Billingsley K, Sheppard B. Predicting malignant intraductal papillary mucinous neoplasm: a single-center review. The American Journal Of Surgery 2011, 201: 575-579. PMID: 21545902, DOI: 10.1016/j.amjsurg.2011.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, MucinousAdultAgedAged, 80 and overCarcinoma, Pancreatic DuctalCarcinoma, PapillaryDiagnosis, DifferentialEndosonographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPancreatectomyPancreatic NeoplasmsPrognosisRetrospective StudiesSurvival RateTime FactorsTomography, X-Ray ComputedUnited StatesConceptsIntraductal papillary mucinous neoplasmInternational consensus guidelinesMalignant intraductal papillary mucinous neoplasmPapillary mucinous neoplasmConsensus guidelinesMucinous neoplasmsInvasive cancerMain duct intraductal papillary mucinous neoplasmPancreatic intraductal papillary mucinous neoplasmsPercent of patientsSingle-center reviewHigh-grade dysplasiaMayo criteriaWorse survivalPatient groupFemale sexSingle institutionMayo ClinicLower riskPatientsMultivariate analysisCancerResectionMain ductNeoplasms
2008
Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest Oncology Group study (S0336)
Whitehead R, Rankin C, Hoff P, Gold P, Billingsley K, Chapman R, Wong L, Ward J, Abbruzzese J, Blanke C. Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest Oncology Group study (S0336). Investigational New Drugs 2008, 27: 469. PMID: 18941712, PMCID: PMC3024913, DOI: 10.1007/s10637-008-9190-8.Peer-Reviewed Original ResearchConceptsMetastatic colorectal cancerColorectal cancerPerformance statusSouthwest Oncology Group studyAdequate bone marrowCombination of romidepsinPrior chemotherapy regimenPrior chemotherapy regimensSignificant cardiac diseaseHuman tumor xenograft modelsAdvanced colorectal cancerPhase II trialColorectal cancer patientsGroup of patientsTreatment of patientsTumor growth inhibitionTumor xenograft modelHistone deacetylase inhibitorsEligible patientsPrior chemotherapyPrior regimensStable diseaseAdvanced diseaseChemotherapy regimenChemotherapy regimensDiagnostic Laparoscopy for Patients with Potentially Resectable Pancreatic Adenocarcinoma: Is It Cost-Effective in the Current Era?
Enestvedt C, Mayo S, Diggs B, Mori M, Austin D, Shipley D, Sheppard B, Billingsley K. Diagnostic Laparoscopy for Patients with Potentially Resectable Pancreatic Adenocarcinoma: Is It Cost-Effective in the Current Era? Journal Of Gastrointestinal Surgery 2008, 12: 1177-1184. PMID: 18470572, DOI: 10.1007/s11605-008-0514-y.Peer-Reviewed Original ResearchConceptsDiagnostic laparoscopyPancreatic cancerPancreatic adenocarcinomaUtilization of laparoscopyResectable pancreatic cancerResectable pancreatic adenocarcinomaPancreatic cancer databaseUse of laparoscopyState Cancer RegistryMedical record dataBiliary bypassPreoperative laparoscopyResectable patientsUnderwent laparoscopyUnresectable diseaseLaparoscopic explorationPeritoneal metastasisCancer RegistryStaging modalitiesCancer DatabaseAverage hospitalLaparoscopyMedicare dataPhysician chargesPatients