NBLDA: negative binomial linear discriminant analysis for RNA-Seq data
Dong K, Zhao H, Tong T, Wan X. NBLDA: negative binomial linear discriminant analysis for RNA-Seq data. BMC Bioinformatics 2016, 17: 369. PMID: 27623864, PMCID: PMC5022247, DOI: 10.1186/s12859-016-1208-1.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBinomial DistributionDiscriminant AnalysisHumansRNASequence Analysis, RNATranscriptomeConceptsNegative binomial linear discriminant analysisNegative binomial distributionNegative binomial variablesPresence of overdispersionBinomial distributionSimulation resultsUnknown parametersNegative binomial modelBinomial modelReal RNA-seq data setsRNA-seq data classificationStatistical methodsDispersion parametersCount dataR codePoisson assumptionLinear discriminant analysisReal-world applicationsPoisson distributionImpact of dispersionDiscrete natureBinomial variablesComparison resultsBinomial classifierWitten