Retinal waves prime visual motion detection by simulating future optic flow
Ge X, Zhang K, Gribizis A, Hamodi AS, Sabino AM, Crair MC. Retinal waves prime visual motion detection by simulating future optic flow. Science 2021, 373 PMID: 34437090, PMCID: PMC8841103, DOI: 10.1126/science.abd0830.Peer-Reviewed Original ResearchConceptsEye-specific segregationSpontaneous retinal wavesVisual response propertiesSpontaneous retinal activityDirection-selective responsesSuperior colliculus neuronsOptic flow patternsRetinal wavesRetinal activityColliculus neuronsRetinal circuitsSpontaneous activityChronic disruptionVisual motion detectionEye openingTransient windowResponse propertiesOptic flowSensory experienceNeuronsPhotoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina
Pottackal J, Walsh HL, Rahmani P, Zhang K, Justice NJ, Demb JB. Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina. Journal Of Neuroscience 2021, 41: 1489-1504. PMID: 33397711, PMCID: PMC7896016, DOI: 10.1523/jneurosci.0674-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAmacrine CellsAnimalsCorticotropin-Releasing HormoneElectrophysiological PhenomenaExcitatory Postsynaptic PotentialsFemaleGamma-Aminobutyric AcidGap JunctionsMaleMiceMice, Inbred C57BLNeural InhibitionNeuronsOptogeneticsPhotoreceptor Cells, VertebrateRetinaRetinal Cone Photoreceptor CellsRetinal Ganglion CellsRetinal Rod Photoreceptor CellsRod OpsinsSynapsesConceptsGap junction-mediated electrical synapsesAmacrine cellsElectrical synapsesIpRGC activityGanglion cellsRetinal interneuronsRetinal circuitsPhotosensitive retinal ganglion cellsGABAergic amacrine cellsRetinal ganglion cellsWhole-cell recordingsSpecific RGC typesAbsence of rodsIpRGC typesRGC typesPharmacological blockadeRetinal neuronsMelanopsin expressionMature retinaMouse retinaSynaptic circuitsNeuronal circuitsInterneuronsOptogenetic stimulationLocal inhibition