Quantitative Evaluation and Optimization of Co-drugging to Improve Anti-HIV Latency Therapy
Wong VC, Fong LE, Adams NM, Xue Q, Dey SS, Miller-Jensen K. Quantitative Evaluation and Optimization of Co-drugging to Improve Anti-HIV Latency Therapy. Cellular And Molecular Bioengineering 2014, 7: 320-333. PMID: 26191086, PMCID: PMC4501041, DOI: 10.1007/s12195-014-0336-9.Peer-Reviewed Original ResearchLatency-reversing agentsLatent infectionSingle drugPrimary T-cell modelLatent cellular reservoirsActivation thresholdHistone deacetylase inhibitorsT cell modelLatent HIVUnwanted side effectsInfected patientsCellular reservoirsDrug interactionsTherapeutic strategiesSide effectsRepeat stimulationDeacetylase inhibitorsViral activationInfectionFurther studiesHIVViral integrationDrugsCell modelViral promoters