2017
Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells
Fong LE, Sulistijo ES, Miller-Jensen K. Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells. Scientific Reports 2017, 7: 16179. PMID: 29170390, PMCID: PMC5701066, DOI: 10.1038/s41598-017-15532-0.Peer-Reviewed Original ResearchConceptsInfected T cellsT cellsT cell reservoirCell deathPMA/ionomycinCD3/CD28Phosphorylation of IκBαViral protein expressionPhosphorylation signaturesHIV eradicationLatent CD4HIV reactivationLatent reservoirLatent HIVActivation of p38Latent infectionClinical strategiesViral latencyViral expressionProtein expressionUninfected cellsInfected cellsDeathCD4Cell reservoir
2014
Quantitative Evaluation and Optimization of Co-drugging to Improve Anti-HIV Latency Therapy
Wong VC, Fong LE, Adams NM, Xue Q, Dey SS, Miller-Jensen K. Quantitative Evaluation and Optimization of Co-drugging to Improve Anti-HIV Latency Therapy. Cellular And Molecular Bioengineering 2014, 7: 320-333. PMID: 26191086, PMCID: PMC4501041, DOI: 10.1007/s12195-014-0336-9.Peer-Reviewed Original ResearchLatency-reversing agentsLatent infectionSingle drugPrimary T-cell modelLatent cellular reservoirsActivation thresholdHistone deacetylase inhibitorsT cell modelLatent HIVUnwanted side effectsInfected patientsCellular reservoirsDrug interactionsTherapeutic strategiesSide effectsRepeat stimulationDeacetylase inhibitorsViral activationInfectionFurther studiesHIVViral integrationDrugsCell modelViral promoters