Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response
Alexander AF, Kelsey I, Forbes H, Miller-Jensen K. Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response. Cell Reports 2021, 36: 109728. PMID: 34551303, PMCID: PMC8995750, DOI: 10.1016/j.celrep.2021.109728.Peer-Reviewed Original ResearchConceptsIL-10Inflammatory responseCytokine secretionAnti-inflammatory cytokine interleukin-10Toll-like receptor 4 stimulationCytokine interleukin-10IL-10 signalingInhibits TLR4Interleukin-10Inflammatory activationProinflammatory activation