2021
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2021, 6: 547-558. PMID: 33915090, PMCID: PMC8192305, DOI: 10.1016/s2468-1253(21)00074-1.Peer-Reviewed Original ResearchConceptsUrsodeoxycholic acid treatmentPrevalence of stillbirthIndividual participant dataIntrahepatic cholestasisBile acid concentrationsUrsodeoxycholic acidComposite outcomeParticipant dataPerinatal outcomesPreterm birthSystematic reviewIndividual participant data analysisLow overall event rateComposite of stillbirthMain secondary outcomesUnpublished cohort studiesAdverse perinatal outcomesMore study participantsOverall event rateTwo-arm studyWeb of ScienceCohort studySecondary outcomesSingleton pregnanciesPrimary outcome
2019
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses
Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Illio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiú MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackienė J, Koster MPH, Kowalska-Kańka A, Kupčinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. The Lancet 2019, 393: 899-909. PMID: 30773280, PMCID: PMC6396441, DOI: 10.1016/s0140-6736(18)31877-4.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAspartate AminotransferasesBile Acids and SaltsBilirubinBiomarkersCase-Control StudiesCholestasis, IntrahepaticCohort StudiesFemaleHumansInfant, NewbornPerinatal DeathPregnancyPregnancy ComplicationsPremature BirthRandomized Controlled Trials as TopicRisk FactorsROC CurveStillbirthConceptsSerum bile acid concentrationsBile acid concentrationsIndividual patient dataAdverse perinatal outcomesRisk of stillbirthPerinatal outcomesTotal bile acidsIntrahepatic cholestasisSingleton pregnanciesBile acidsBiochemical markersPregnancy casesHigh riskSerum total bile acidsTotal bile acid concentrationAdverse perinatal effectsPatient dataElevated bile acid concentrationsPopulation-based studyCase-control studyPrevalence of stillbirthUK National InstituteStepwise logistic regressionSpecific biochemical markersFull-text articles